CLINICAL, BIOCHEMICAL AND MORPHOLOGIC FEATURES OF ACNE KELOIDALIS IN A BLACK-POPULATION
CLINICAL, BIOCHEMICAL AND MORPHOLOGIC FEATURES OF ACNE KELOIDALIS IN A BLACK-POPULATION
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DOI：
10.1111/j.1365-4362.1993.tb02739.x
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发表时间：
1993-10-01
影响因子：
3.6
通讯作者：
ODUSAN, O
中科院分区：
文献类型：
--
作者：
GEORGE, AO;AKANJI, AO;ODUSAN, O
背景。瘢痕疙瘩痤疮 (AK) 是尼日利亚发病的重要原因，占尼日利亚皮肤科诊所皮肤病患者的 1.3%。由于发病机制尚不清楚，治疗通常不令人满意。方法。进行了一项前瞻性临床病理学研究，以确定诱发因素、可行的治疗方式和预后指标。结果。研究表明AK与男性脂溢性体质、早育年龄和空腹血液睾酮浓度升高有关。可能导致枕骨部位病变的特征包括肥大细胞密度增加和真皮毛细血管扩张。治疗。主要目的是诊断早期丘疹并避免物理和化学创伤剂。视黄酸类似物和抗雄激素可能有帮助。结论。广泛使用刺激性物理和化学传统治疗方法以及延迟就医（AK 通常是无症状的）导致该疾病在就诊时处于相对晚期的状态。
Background. Acne keloidalis (AK) is an important cause of morbidity in Nigeria and accounts for 1.3% of patients with skin conditions in a Nigerian dermatology clinic. Treatment is usually unsatisfactory because the etiopathogenesis is unclear.Methods. A prospective clinico-pathological study was carried out to identify predisposing factors, viable treatment modalities, and prognostic indicators.Results. The study suggested that AK is associated with the male gender seborrheic constitution, early reproductive years, and increased fasting blood testosterone concentration. Features that may predispose to the vastly predominant occipital location of the lesions include increased mast cell density and dilatation of dermal capillaries.Management. The main aims are diagnosis of early papules and avoidance of physical and chemical traumatizing agents. Retinoic acid analogs and antiandrogens may be helpful.Conclusions. The widespread use of irritating physical and chemical traditional treatment remedies and delay in seeking medical attention-AK is typically asymptomatic-contribute to the relatively advanced nature of the disease at the time of presentation to the specialist.