Land-Applied Goat Manure as a Source of Human Q-Fever in the Netherlands, 2006-2010
Land-Applied Goat Manure as a Source of Human Q-Fever in the Netherlands, 2006-2010
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DOI：
10.1371/journal.pone.0096607
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发表时间：
2014-05-02
期刊：
影响因子：
3.7
通讯作者：
Hoebe, Christian
中科院分区：
文献类型：
--
作者：
Hermans, Tia;Jeurissen, Leonne;Hoebe, Christian
研究表明，Q热阳性农场（QFPF）和人类Q热社区病例之间存在联系。我们的研究是第一个调查受污染的土地施用粪便在人类Q热中的潜在作用，基于大量的全国范围内的通知和农场管理数据。在地理上有联系的已报告人间病例中，施用粪肥和发病之间的时间与Q热的潜伏期相吻合。受污染地块的接近程度比QFPF的接近程度更能预测人间病例（2009年为80%对58%，0-5公里）。QFPF和污染地块周围的发病率随距离的增加而下降，但在非污染地块周围则不然。污染地块周围的发病率高于非污染地块（RR = [10]，95%CI = [7，1 - 14，2]）。我们的研究结果提供的证据表明，除了QFPF，土地施用的污染粪便可能是人类Q热的另一个来源。
Studies have shown a link between Q-fever positive farms (QFPFs) and community cases of human Q-fever. Our study is the first to investigate the potential role of contaminated land-applied manure in human Q-fever, based on a large set of nationwide notification and farm management data. Time between manure application and disease onset in geographically linked notified human cases coincided with the incubation period of Q-fever. Proximity of contaminated land parcels predicted human cases better than proximity of QFPFs (80% vs. 58%, 0-5 km in 2009). Incidence around QFPFs and contaminated land parcels decreased with distance, but not around non-contaminated land parcels. Incidence was higher around contaminated land parcels than non-contaminated land parcels (RR = [10], 95%CI = [7,1-14,2]). Our findings deliver evidence that, apart from QFPFs, land-applied contaminated manure may be another source of human Q-fever.