Lipid profiling reveals the presence of unique lipid mediators in human milk from healthy and mastitic subjects
Lipid profiling reveals the presence of unique lipid mediators in human milk from healthy and mastitic subjects
复制标题
脂质分析揭示了健康和乳腺炎受试者的母乳中存在独特的脂质介质
DOI：
10.1016/j.bbrc.2022.09.051
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发表时间：
2022
影响因子：
3.1
通讯作者：
Suzuki-Yamamoto Toshiko
中科院分区：
文献类型：
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作者：
Nagasaki Yuki;Kawai Erika;Maruoka Saya;Osumi Miho;Tsukayama Izumi;Kawakami Yuki;Takahashi Yoshitaka;Okazaki Yuka;Miki Yoshimi;Taketomi Yoshitaka;Yamamoto Kei;Murakami Makoto;Suzuki-Yamamoto Toshiko
乳脂质是婴儿重要的能量来源，但乳脂质的组成尚未详细阐明。在这项研究中，我们分析了来自人类和奶牛的牛奶中的游离脂肪酸及其代谢产物。与牛乳相比，人乳显示出更高含量的游离脂肪酸，包括多不饱和脂肪酸，尤其是ω-3脂肪酸及其代谢产物。多不饱和脂肪酸丰富的哺乳期的早期，而饱和脂肪酸并没有显着变化。此外，人乳含有高水平的ω-3脂肪酸代谢物，特别是18-羟基二十碳五烯酸，一种具有抗炎活性的二十碳五烯酸衍生代谢物。与正常人乳汁相比，乳腺炎患者乳汁中血栓素B2和保护素D1水平显著升高，提示这些脂质介质可能是阻塞性乳腺炎的潜在生物标志物。总体而言，母乳的独特脂质特征支持母乳喂养的功效，与人工或牛奶相比，母乳为婴儿提供更多营养和生物活性脂质，婴儿的消化和吸收功能仍不成熟。
Milk lipids are an important energy source for infants, but the composition of milk lipids has not yet been clarified in detail. In this study, we analyzed free fatty acids and their metabolites in milk from humans and cows. In comparison to cow milk, human milk showed a higher content of free fatty acids including polyunsaturated fatty acids, especially ω-3 fatty acids and their metabolites. Polyunsaturated fatty acids were enriched at an early period of lactation, while saturated fatty acids did not change significantly over the period. Moreover, human milk contained high levels of ω-3 fatty acid metabolites, particularly 18-hydroxyeicosapentaenoic acid, an eicosapentaenoic acid-derived metabolite with anti-inflammatory activity. In comparison with human normal milk, thromboxane B2and protectin D1 levels were significantly elevated in milk from individuals with mastitis, suggesting that these lipid mediators could be potential biomarkers of obstructive mastitis. Overall, the unique lipid profile of human milk supports the efficacy of breast-feeding for supply of more nutritional and bioactive lipids in comparison to artificial or cow milk to infants, in whom digestive and absorptive functions are still immature.