KYNURENIC ACID BLOCKS NEUROTOXICITY AND SEIZURES INDUCED IN RATS BY THE RELATED BRAIN METABOLITE QUINOLINIC ACID
KYNURENIC ACID BLOCKS NEUROTOXICITY AND SEIZURES INDUCED IN RATS BY THE RELATED BRAIN METABOLITE QUINOLINIC ACID
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DOI：
10.1016/0304-3940(84)90050-8
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发表时间：
1984-01-01
影响因子：
2.5
通讯作者：
SCHWARCZ, R
中科院分区：
文献类型：
--
作者：
FOSTER, AC;VEZZANI, A;SCHWARCZ, R
犬尿酸 (KYNA) 被测试为代谢相关脑成分喹啉酸 (QUIN) 的神经毒性和致癫痫作用的拮抗剂。在大鼠纹状体中，KYNA 优先于其他兴奋毒素阻断 QUIN 的神经毒性作用。在海马体中，KYNA 可以拮抗 QUIN 局部应用引起的神经变性和癫痫发作。 KYNA 的这些特性提出了大脑中 KYNA 和 QUIN 之间功能联系的可能性，这可能与理解人类神经退行性疾病相关。
Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic effects of the metabolically related brain constituent quinolinic acid (QUIN). In the rat striatum, KYNA blocked the neurotoxic effects of QUIN in preference to those of other excitotoxins. In the hippocampus, KYNA antagonized both the neurodegeneration and seizures caused by the local application of QUIN. These properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders.