HIV-1 infection in rural Africa: is there a difference in median time to AIDS and survival compared with that in industrialized countries?
HIV-1 infection in rural Africa: is there a difference in median time to AIDS and survival compared with that in industrialized countries?
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DOI：
10.1097/00002030-200203080-00011
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发表时间：
2002-03-08
期刊：
影响因子：
3.8
通讯作者：
Whitworth, JAG
中科院分区：
文献类型：
--
作者：
Morgan, D;Mahe, C;Whitworth, JAG
目的：描述乌干达农村地区HIV-1感染从血清转化到艾滋病和死亡的进展时间，以及从首次出现艾滋病到死亡的时间。此外，描述的队列内死于艾滋病和CD 4淋巴细胞计数deads.Design：一个前瞻性的，纵向的，以人口为基础的coherent.Methods：自1990年以来，107艾滋病毒流行的情况下，168例事件和235艾滋病毒血清阴性对照组已被招募到一个队列在乌干达农村。参与者从普通人群中招募，每3个月和其他生病时间进行一次常规检查。结果：从血清转化到死亡的中位时间为9.8年。血清转换时年龄超过40岁与更快的进展相关（P < 0.001，对数秩检验）。在研究的前4年，艾滋病毒对艾滋病毒事件病例的死亡率贡献很小，但5年后，艾滋病毒的贡献变得更大，在最老年龄组中尤其明显。队列中的生存率与一般人群相似。从血清转换到艾滋病的中位时间为9.4年，从艾滋病到死亡的中位时间为9.2个月。在感染HIV-1的人中，80%死于艾滋病，20%的人CD 4计数< 10 × 101个细胞/l。结论：在非洲，HIV-1感染者的生存率与使用抗逆转录病毒治疗前的工业化国家相似;当他们死亡时，许多非洲人严重免疫抑制，大多数人具有艾滋病的临床特征。(C)2002年利平科特威廉姆斯威尔金斯。
Objectives: To describe the progression times of HIV-1 infection from seroconversion to AIDS and to death, and time from first developing AIDS to death in rural Uganda. Also, to describe the proportion of individuals within the cohort dying with AIDS and the CD4 lymphocyte count before death.Design: A prospective, longitudinal, population-based cohort.Methods: Since 1990, 107 HIV-prevalent cases, 168 incident cases and 235 HIV-seronegative controls have been recruited into a cohort in rural Uganda. Participants are recruited from the general population and they are reviewed routinely every 3 months and at other times when ill.Results: The median time from seroconversion to death was 9.8 years. Age over 40 years at seroconversion was associated with more rapid progression (P < 0.001, log rank test). For the first 4 years of the study, HIV contributed little to the death rates in the HIV incident cases, but after 5 years, the contribution of HIV became greater and was particularly marked in the oldest age group. Survival rates in the cohort were similar to those in the general population. The median time from seroconversion to AIDS was 9.4 years and from AIDS to death was 9.2 months. Of those infected with HIV-1, 80% died with AIDS and 20% had a CD4 count < 10 X 101 cells/l.Conclusions: Survival with HIV-1 infection is similar in Africa to industrialized countries before the use of antiretroviral therapy; when they do die, many of those in Africa are severely immunosuppressed and most have clinical features of AIDS. (C) 2002 Lippincott Williams Wilkins.