Under the Skin: The Relationship Between Subcutaneous Injection and Skin Infections Among People Who Inject Drugs.
Under the Skin: The Relationship Between Subcutaneous Injection and Skin Infections Among People Who Inject Drugs.
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DOI：
10.1097/adm.0000000000000844
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发表时间：
2022-03-01
影响因子：
5.5
通讯作者：
Stein MD
中科院分区：
文献类型：
--
作者：
Freibott CE;Phillips KT;Anderson BJ;Stewart C;Liebschutz JM;Stein MD
注射毒品（PWID）的人面临着许多负面健康结果的风险增加。皮下注射（又名皮肤爆裂）可能导致皮肤和软组织感染（SSTI）的风险更大，但对选择这种给药途径的PWID知之甚少。本研究比较了皮下注射器静脉注射器，那些谁皮下注射的特点，并检查皮下注射是否与SSTI在过去的一年。一个队列的住院PWID（n=252）进行了采访，关于注射相关的行为，SSTI的历史，和知识的皮下注射的风险。我们检查了那些做和不做皮下注射的人之间的差异，并使用负二项回归模型来估计皮下注射和SSTI相关的调整后的比值。参与者平均年龄为38岁，其中58.3%为男性，59.5%为白色，20.6%为黑人，15.9%为拉丁裔。进行皮下注射的PWID与其他PWID在人口统计学上没有差异;然而，皮下注射者过去一年SSTI的平均发生率高于未进行皮下注射者（1.98 vs 0.96，p<0.001）。皮下注射的人与静脉注射的人在皮下注射风险的知识方面没有差异（p= 0.112），知识得分与SSTI无关（p= 0.457）。进行皮下注射的PWID在人口统计学上与其他PWID相似，但过去一年SSTI的发生率较高。皮下注射风险的知识与SSTI风险无关。
People who inject drugs (PWID) are at increased risk for numerous negative health outcomes. Subcutaneous injections (aka skin popping) can result in greater risk of skin and soft tissue infections (SSTIs), but less is known about PWID who choose this route of administration. This study compares subcutaneous injectors to intravenous injectors, characterizes those who inject subcutaneously, and examines whether subcutaneous injection is associated with SSTIs in the past year. A cohort of hospitalized PWID (n=252) were interviewed regarding injection-related behaviors, history of SSTI, and knowledge of subcutaneous injection risk. We examined differences between those who do and do not inject subcutaneously and used a negative binomial regression model to estimate adjusted odds associating subcutaneous injection and SSTI. Participants averaged 38 years, with 58.3% male, 59.5% White, 20.6% Black, and 15.9% Latinx. PWID who performed subcutaneous injection were not demographically different from other PWID; however, the mean rate of past year SSTIs was higher for persons injecting subcutaneously than for those who did not (1.98 vs 0.96, p<.001). Persons injecting subcutaneously did not differ from those who injected intravenously in terms of their knowledge of subcutaneous injection risk (p=.112) and knowledge score was not associated with SSTIs (p=.457). PWID who perform subcutaneous injections are demographically similar to other PWID but had higher rates of past year SSTIs. Knowledge of subcutaneous injection risk was not associated with SSTI risk.