Surnames in Sardinia. III. The spatial distribution of surnames for testing neutrality of genes.
Surnames in Sardinia. III. The spatial distribution of surnames for testing neutrality of genes.
复制标题
撒丁岛的姓氏。
DOI：
10.1111/j.1469-1809.1986.tb01036.x
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发表时间：
1986
影响因子：
1.9
通讯作者：
Cavalli-Sforza,LL
中科院分区：
文献类型：
--
作者：
Zei,G;Piazza,A;Moroni,A;Cavalli-Sforza,LL
1.对撒丁岛男性姓氏随时间和空间的异质性进行了研究，使用的数据来自近亲婚姻（1800-1970年）和电话簿（1978年）。姓氏频率随时间的变化不显著，比空间频率低10倍，具有非常显著的空间频率变化。对于频率足够高的姓氏，从空间异质性的χ 2计算的Wahlund方差的估计值与姓氏的频率无关：这提供了中性的证据，与从姓氏的频率分布中获得的一致。Wahlund方差，W（也称为FST），随着所考虑区域的平均大小（每个区域的个体数，N）的增加而有规律地减少。关系式W = KNβ中参数β的估计对研究种群结构有意义.考虑到它们的单倍性传递，对姓氏的变异必须作1/4的校正系数。这表明姓氏可以为估计随机遗传漂变下的Wahlund方差值提供基线，从而评估基因是否表现为选择性中性。从两组基因频率数据中获得的Wahlund方差的分布与在相同地区姓氏的可比条件下获得的方差的分布相比，似乎表明大多数基因表现为中性，除了少数具有高W值的基因，这可能是在所研究的地区处于不同的选择压力下。
1. A study on heterogeneity of males' surnames over time and space in the island of Sardinia was carried out using data from consanguineous marriages (1800–1970) and telephone directories (1978).2. Variation of frequency of surnames over time is barely significant and 10 times lower than that over space, which is very highly singificant.3. For sufficiently frequent surnames the estimate of the Wahlund variance, calculated form χ2for heterogeneity in space, is independent of the frequency of a surname: this supplies evidence of neutrality in line with that obtained from the frequency distribution of surnames.4. The Wahlund variance,W(also called FST), decreases regularly as the average size of the area considered (number of individuals per area,N) increases. The estimate of the parameter β in the relationW = KNβcould be of interest for the study of population structure.5. A correction factor of 1/4 must be made on the surnames' variance in consideration of their haploid unisexual transmission.6. It is suggested that surnames could provide a baseline for estimating the value of Wahlund variance under random genetic drift and hence evaluating whether a gene behaves as selectively neutral.7. The distribution of the Wahlund variances obtained from two sets of gene frequency data as compared with that obtained in comparable conditions for surnames in the same areas seems to show that most genes behave as neutral, with the exception of a few, with highWvalues, which presumably have been under different selection pressures in the area examined.