COMPARISONS OF VERBAL FLUENCY TASKS IN THE DETECTION OF DEMENTIA OF THE ALZHEIMER TYPE
COMPARISONS OF VERBAL FLUENCY TASKS IN THE DETECTION OF DEMENTIA OF THE ALZHEIMER TYPE
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DOI：
10.1001/archneur.1992.00530360051017
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发表时间：
1992-12-01
影响因子：
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通讯作者：
THAL, LJ
中科院分区：
文献类型：
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作者：
MONSCH, AU;BONDI, MW;THAL, LJ
对89例阿尔茨海默型痴呆（DAT）患者和53例人口统计学匹配的老年正常对照组进行了四项语言流畅性测量（类别、字母、名字和超市流畅性）的比较。绘制受试者工作特征曲线，以确定每个流畅性任务的敏感性（即，真阳性率）和特异性（即，真阴性率）。类别流畅性表现出最大程度的区分DAT患者和正常对照组（敏感性，100%;特异性，92.5%）;字母流畅性是最不准确的（敏感性，89%;特异性，85%）。按性别对DAT患者的分离显示了类似的结果。在对21例轻度受损DAT患者的亚组进行的进一步分析中，类别流畅性没有丧失其辨别能力，而所有其他流畅性指标显示辨别能力明显降低。我们的结论是，这种优势的类别流畅性是由于其依赖于结构的语义知识，恶化的早期阶段的DAT。
The performances of 89 patients with dementia of the Alzheimer type (DAT) and 53 demographically matched elderly normal control subjects were compared on four verbal fluency measures (category, letter, first names, and supermarket fluency). Receiver operating characteristic curves were plotted to determine each fluency tasks' sensitivity (ie, true-positive rate) and specificity (ie, true-negative rate). Category fluency demonstrated the greatest degree of discrimination between patients with DAT and normal control subjects (sensitivity, 100%; specificity, 92.5%); letter fluency was the least accurate (sensitivity, 89%; specificity, 85%). Separation of patients with DAT by gender revealed similar findings. In further analyses with a subgroup of 21 mildly impaired patients with DAT, category fluency lost none of its discriminative capabilities, whereas all other fluency measures showed marked reductions in discriminability. We conclude that this superiority of category fluency is due to its dependence on the structure of semantic knowledge, which deteriorates in the early stages of DAT.