REDUCTION OF BACTERIURIA AND PYURIA AFTER INGESTION OF CRANBERRY JUICE
REDUCTION OF BACTERIURIA AND PYURIA AFTER INGESTION OF CRANBERRY JUICE
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DOI：
10.1001/jama.271.10.751
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发表时间：
1994-03-09
影响因子：
120.7
通讯作者：
LIPSITZ, LA
中科院分区：
文献类型：
--
作者：
AVORN, J;MONANE, M;LIPSITZ, LA
客观。-探讨定期饮用蔓越莓汁饮料对老年妇女菌尿和脓尿的影响。设计。-随机、双盲、安慰剂对照试验。实验对象。志愿者样本153老年妇女（平均年龄，78.5岁）。干预。-受试者被随机分配每天消耗300公吨的市售标准蔓越莓饮料或专门制备的合成安慰剂饮料，其在味道、外观和维生素C含量上难以区分，但缺乏蔓越莓含量。结果测量。每隔约1个月采集一份基线尿样和6份清洁排泄的研究尿样，并定量检测菌尿和是否存在白色血细胞。结果。-随机分配到蔓越莓饮料组的受试者发生菌尿（定义为细菌数量大于或等于10（5）/mL）伴脓尿的几率仅为对照组的42%（P= 0.004）。考虑到他们在前一个月有细菌性脓尿，他们保持细菌性脓尿的几率只有对照组的27%（P= 0.006）。结论。这些研究结果表明，使用蔓越莓饮料可以减少老年妇女细菌尿伴脓尿的频率。关于蔓越莓汁对尿路影响的普遍看法可能有微生物学的理由。
Objective.-To determine the effect of regular intake of cranberry juice beverage on bacteriuria and pyuria in elderly women. Design.-Randomized, double-blind, placebo-controlled trial. Subjects.-Volunteer sample of 153 elderly women (mean age, 78.5 years). Intervention.-Subjects were randomly assigned to consume 300 mt per day of a commercially available standard cranberry beverage or a specially prepared synthetic placebo drink that was indistinguishable in taste, appearance, and vitamin C content but lacked cranberry content. Outcome Measures.-A baseline urine sample and six clean-voided study urine samples were collected at approximately 1-month intervals and tested quantitatively for bacteriuria and the presence of white blood cells. Results.-Subjects randomized to the cranberry beverage had odds of bacteriuria (defined as organisms numbering greater than or equal to 10(5)/mL) with pyuria that were only 42% of the odds in the control group (P=.004). Their odds of remaining bacteriuric-pyuric, given that they were bacteriuric-pyuric in the previous month, were only 27% of the odds in the control group (P=.006). Conclusions.-These findings suggest that use of a cranberry beverage reduces the frequency of bacteriuria with pyuria in older women. Prevalent beliefs about the effects of cranberry juice on the urinary tract may have microbiologic justification.