Cholinergic Modulation of the Resonance Properties of Stellate Cells in Layer II of Medial Entorhinal Cortex
Cholinergic Modulation of the Resonance Properties of Stellate Cells in Layer II of Medial Entorhinal Cortex
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DOI：
10.1152/jn.00492.2009
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发表时间：
2010-07-01
影响因子：
2.5
通讯作者：
Hasselmo, Michael E.
中科院分区：
文献类型：
--
作者：
Heys, James G.;Giocomo, Lisa M.;Hasselmo, Michael E.
Heys JG，Giocomo LM，Hasselmo ME。内侧内嗅皮层第二层星状细胞共振特性的胆碱能调制。J Neurophysiol 104：258-270，2010.首次发表于2010年5月5日; doi：10.1152/jn.00492.2009。在体外全细胞膜片钳记录的星状细胞在第二层的内侧内嗅皮层显示阈下膜电位共振响应于正弦电流注入的不同频率。清醒行为动物的生理记录显示，第二层内侧内嗅皮层中的神经元（称为“网格细胞”）以空间选择性的方式发射，使得每个细胞的多个发射场形成六边形网格。网格场的空间周期性和共振频率在沿着内侧内嗅皮层背腹轴的神经元中发生系统性变化。先前的工作也表明，网格场间距和乙酰胆碱水平的变化作为一个功能的新奇性，以一个特定的环境。使用体外全细胞膜片钳记录，我们的研究表明，共振频率和共振强度作为胆碱能调制的函数而变化。此外，我们的数据表明，这些变化的共振特性介导的调制的H-电流和M-电流。
Heys JG, Giocomo LM, Hasselmo ME. Cholinergic modulation of the resonance properties of stellate cells in layer II of medial entorhinal cortex. J Neurophysiol 104: 258-270, 2010. First published May 5, 2010; doi:10.1152/jn.00492.2009. In vitro whole cell patch-clamp recordings of stellate cells in layer II of medial entorhinal cortex show a subthreshold membrane potential resonance in response to a sinusoidal current injection of varying frequency. Physiological recordings from awake behaving animals show that neurons in layer II medial entorhinal cortex, termed "grid cells," fire in a spatially selective manner such that each cell's multiple firing fields form a hexagonal grid. Both the spatial periodicity of the grid fields and the resonance frequency change systematically in neurons along the dorsal to ventral axis of medial entorhinal cortex. Previous work has also shown that grid field spacing and acetylcholine levels change as a function of the novelty to a particular environment. Using in vitro whole cell patch-clamp recordings, our study shows that both resonance frequency and resonance strength vary as a function of cholinergic modulation. Furthermore, our data suggest that these changes in resonance properties are mediated through modulation of h-current and m-current.