Imaging brain connectivity in children with diverse reading ability
Imaging brain connectivity in children with diverse reading ability
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DOI：
10.1016/j.neuroimage.2004.12.053
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发表时间：
2005-05-01
期刊：
影响因子：
5.7
通讯作者：
Phillips, L
中科院分区：
文献类型：
--
作者：
Beaulieu, C;Plewes, C;Phillips, L
阅读是一项复杂的认知技能，需要大脑多个区域的协调。尽管功能性神经成像研究强调了与特定认知任务（如阅读）相关的大脑皮层区域，但它们并没有直接解决有效执行该任务所必需的潜在神经连接。患有阅读障碍的成年人表现出较低的区域白质连通性，但尚不清楚神经元连接和阅读表现之间的这种关系是否也适用于年轻读者。通过使用弥散张量磁共振成像（DTI）来突出大脑连线的结构完整性，我们发现在8-12岁的儿童中，左侧颞顶叶白质的区域大脑连接与广泛的阅读能力相关。扩散张量示神经束图显示，内囊后肢与阅读能力（单词识别子测试）与分数各向异性之间最大相关簇的位置一致。白质的成熟可能在认知过程（如阅读）的发展中起着关键作用。©2005 Elsevier Inc.版权所有。
Reading is a complex cognitive skill that requires the coordination of multiple brain regions. Although functional neuroimaging studies highlight the cortical brain regions associated with a specific cognitive task like reading, they do not directly address the underlying neural connections necessary for efficient performance of this task. Adults with reading disability have demonstrated lower regional white matter connectivity, but it is not known whether this relationship between neuronal wiring and reading performance also holds in younger readers. Using diffusion tensor magnetic resonance imaging (DTI) that highlights the structural integrity of the brain wiring, we show that regional brain connectivity in the left temporo-parietal white matter correlates with a wide range of reading ability in children as young as 8-12 years old. Diffusion tensor tractography suggests that the posterior limb of the internal capsule is consistent with the location of the largest cluster of correlation between reading ability (Word Identification subtest) and fractional anisotropy. The maturation of the white matter may play a key role in the development of cognitive processes such as reading. © 2005 Elsevier Inc. All rights reserved.