Nil effects of μ-rhythm phase-dependent burst-rTMS on cortical excitability in humans: A resting-state EEG and TMS-EEG study
Nil effects of μ-rhythm phase-dependent burst-rTMS on cortical excitability in humans: A resting-state EEG and TMS-EEG study
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DOI：
10.1371/journal.pone.0208747
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发表时间：
2018-12-07
期刊：
影响因子：
3.7
通讯作者：
Belardinelli, Paolo
中科院分区：
文献类型：
--
作者：
Desideri, Debora;Zrenner, Christoph;Belardinelli, Paolo
重复性经颅磁刺激(RTMS)可通过突触可塑性机制诱导受刺激脑区兴奋性改变。高频(100赫兹)rTMS的三联体与持续感觉运动节律的负峰同步，而不是与同时获得的脑电(EEG)分离的正峰同步，导致可重现的长期增强，如运动诱发电位(MEP)幅度的增加，这是皮质脊髓兴奋性的指标(Zrenner等人)。2018年，脑筋急转弯11：374-389)在这里，我们分析了来自(Zrenner等人，2018)的EEG和TMS-EEG数据，以研究p-节律-相位相关的猝发-rTMS对基于EEG的皮质兴奋性测量的影响。我们使用静息状态的EEG来评估刺激本身和对侧运动皮质的单位功率和β功率，以及在刺激的运动皮质中使用单脉冲TMS诱发和诱导的EEG反应。我们发现，Mu节律相关的猝发-rTMS没有显著改变这些脑电指标中的任何一个，尽管对MEP幅度存在显著的差异性和可重复性的影响。我们的结论是，皮层兴奋性的脑电测量不能反映以MEP幅度测量的皮质脊髓兴奋性。这很可能是因为rTMS在分子和突触水平上导致了复杂的兴奋和抑制变化，而这在宏观水平上是EEG无法区分的。
Repetitive transcranial magnetic stimulation (rTMS) can induce excitability changes of a stimulated brain area through synaptic plasticity mechanisms. High-frequency (100 Hz) triplets of rTMS synchronized to the negative but not the positive peak of the ongoing sensorimotor mu-rhythm isolated with the concurrently acquired electroencephalography (EEG) resulted in a reproducible long-term potentiation like increase of motor evoked potential (MEP) amplitude, an index of corticospinal excitability (Zrenner et al. 2018, Brain Stimul 11:374-389). Here, we analyzed the EEG and TMS-EEG data from (Zrenner et al., 2018) to investigate the effects of p-rhythm-phase-dependent burst-rTMS on EEG-based measures of cortical excitability. We used resting-state EEG to assess mu- and beta-power in the motor cortex ipsi- and contralateral to the stimulation, and single-pulse TMS-evoked and induced EEG responses in the stimulated motor cortex. We found that mu-rhythm-phase-dependent burst-rTMS did not significantly change any of these EEG measures, despite the presence of a significant differential and reproducible effect on MEP amplitude. We conclude that EEG measures of cortical excitability do not reflect corticospinal excitability as measured by MEP amplitude. Most likely this is explained by the fact that rTMS induces complex changes at the molecular and synaptic level towards both excitation and inhibition that cannot be differentiated at the macroscopic level by EEG.