Neurocognitive impairment is an independent risk factor for death in HIV infection
Neurocognitive impairment is an independent risk factor for death in HIV infection
复制标题
DOI：
10.1001/archneur.1997.00550160054016
复制
发表时间：
1997-04-01
影响因子：
--
通讯作者：
Dupont, R
中科院分区：
文献类型：
--
作者：
Ellis, RJ;Deutsch, R;Dupont, R
目的：确定人类免疫缺陷病毒1型（HIV-1）相关的神经认知障碍患者的死亡率是否高于痴呆患者，设计：一项前瞻性队列研究，随访时间中位数为2.4年。Kaplan-Meier分析和考克斯比例风险模型被用来比较生存时间根据neurocognitive classification.Setting：大学为基础的research unit.Participants：一个志愿者样本的414个人HIV-1血清阳性。受试者在基线评估时被分类为神经心理学（NP）正常或异常（在大于或等于2个NP测试领域受损）。NP异常受试者的一个亚组符合HIV相关轻微认知运动障碍的操作标准;其余受试者被指定为NP受损。受试者与坦率的痴呆excluded.Main Outcome Measure：Mortality.Results：在基线评估，256（62%）414名受试者被指定为正常; 109（26%），NP受损;和49（12%），轻微的认知运动障碍。106名参与者（26%）在随访期间死亡。与NP正常组相比，所有NP异常受试者（轻度认知运动障碍和NP受损）的未校正死亡相对危险度（RR，1.7; 95%置信区间[CI]，1.2-2.6; P
Objective: To determine if mortality is increased in individuals with human immunodeficiency virus type 1 (HIV-1)-associated neurocognitive disorders less severe than frank dementia.Design: A prospective cohort study; median duration of follow-up was 2.4 years. Kaplan-Meier analysis and Cox proportional hazards models were used to compare survival times according to neurocognitive classification.Setting: University-based research unit.Participants: A volunteer sample of 414 individuals seropositive for HIV-1. Subjects were classified at their baseline evaluation as neuropsychologically (NP) normal or abnormal (impaired in greater than or equal to 2 NP test domains). A subgroup of NP abnormal subjects met operational criteria for HIV-associated minor cognitive motor disorder; the remaining subjects were designated NP impaired. Subjects with frank dementia were excluded.Main Outcome Measure: Mortality.Results: At the baseline evaluation, 256 (62%) of 414 subjects were designated normal; 109 (26%), NP impaired; and 49 (12%), minor cognitive motor disorder. One hundred six participants (26%) died during followup. Compared with the NP normal group, the unadjusted relative risk (RR) of death for all NP abnormal subjects (minor cognitive motor disorder and NP impaired) was significantly increased (RR, 1.7; 95% confidence interval [CI], 1.2-2.6; P