Is statin use associated with prostate cancer aggressiveness?
Is statin use associated with prostate cancer aggressiveness?
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DOI：
10.1111/j.1464-410x.2009.09007.x
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发表时间：
2010-05-01
影响因子：
4.5
通讯作者：
Catalona, William J.
中科院分区：
文献类型：
--
作者：
Loeb, Stacy;Kan, Donghui;Catalona, William J.
目的进一步研究他汀类药物（3-羟基-3-甲基戊二酰辅酶 A 还原酶抑制剂）与一大群接受根治性前列腺切除术 (RP) 的患者的病理特征之间的关系，因为流行病学研究表明，他汀类药物除了有益的心血管作用外，还可能降低侵袭性前列腺癌的风险。 患者和方法从 2003 年到 2009 年，1351 名男性接受了术前数据。一位外科医生使用他汀类药物导致了 RP。比较了 504 名他汀类药物使用者和 847 名非使用者的临床和病理肿瘤特征。结果他汀类药物使用者明显比非使用者年龄更大，平均体重指数更高。服用他汀类药物的患者术前血清前列腺特异性抗原水平、RP标本中的肿瘤体积和癌症百分比均显着降低。总体而言，他汀类药物使用者的不良肿瘤病理特征发生率相对较低，包括显着较低的阳性（癌性）手术切缘风险。结论我们的结果表明，他汀类药物的使用可能与 RP 中更有利的病理特征相关。长期的疾病特异性结果以及他汀类药物与前列腺癌之间的潜在联系需要进一步研究。
OBJECTIVETo further examine the association between statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) and pathological features in a large group of patients undergoing radical prostatectomy (RP), as epidemiological studies have suggested that statins, in addition to their beneficial cardiovascular effects, might reduce the risk of aggressive prostate cancer.PATIENTS AND METHODSFrom 2003 to 2009, 1351 men with data on preoperative statin use had RP by one surgeon. The clinical and pathological tumour features were compared between 504 users of statins and 847 who were not users.RESULTSStatin users were significantly older and had a higher mean body mass index than non-users. The preoperative serum prostate-specific antigen levels, tumour volume and percentage of cancer in the RP specimen were significantly lower in patients taking statins. Overall, statin users had a proportionately lower rate of adverse tumour pathology features, including a significantly lower risk of positive (cancerous) surgical margins.CONCLUSIONOur results suggest that the use of statins might be associated with more favourable pathological features at RP. The long-term disease-specific outcomes and the underlying link between statins and prostate cancer require further investigation.