Hepatitis B virus genotypes: an overview.
Hepatitis B virus genotypes: an overview.
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DOI：
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发表时间：
2008-10
期刊：
影响因子：
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通讯作者：
M. Mahtab;S. Rahman;Mobin Khan;F. Karim
中科院分区：
文献类型：
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作者：
M. Mahtab;S. Rahman;Mobin Khan;F. Karim
背景：乙肝病毒感染是全球范围内导致死亡和发病的主要原因。这项探索继续确定影响疾病进展和严重程度的病毒因素，以及对乙肝病毒感染治疗的反应。根据乙肝病毒的变异，该病毒被分为几种基因类型。资料来源：对已发表的有关乙肝病毒基因分型的文献进行综述。结果乙肝病毒基因分型可能在决定乙肝病毒所致肝病的严重程度和进展以及对不同抗病毒药物的反应中起重要作用。结论尽管目前尚不推荐将乙肝病毒基因分型用于治疗乙肝病毒感染，但现有数据表明，与丙型肝炎病毒感染一样，在不久的将来，乙肝病毒基因分型也有可能成为治疗乙肝病毒的常规检查方法。
BACKGROUND Hepatitis B virus (HBV) infection is a major cause of mortality and morbidity globally. The quest continues to identify viral factors that influence disease progression and severity as well as responses to treatment of HBV infection. Based on variations in HBV, the virus has been divided into a number of genotypes. DATA SOURCES Review of published literature on HBV genotypes. RESULTS HBV genotypes are likely to be important in determining the severity and progression of HBV-induced liver disease as well as responses to different anti-viral agents. CONCLUSION Although HBV genotyping is not yet recommended for routine use in treating HBV infection, available data suggest that, as in hepatitis C virus infection, HBV genotyping is also likely to become a routine investigation for HBV treatment, perhaps in the not too distant future.