Ovarian cancer-associated proteinases.
Ovarian cancer-associated proteinases.
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卵巢癌相关蛋白酶。
DOI：
10.1007/978-1-4757-3587-1_16
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发表时间：
2002
影响因子：
--
通讯作者：
Stack,MSharon
中科院分区：
文献类型：
--
作者：
Ghosh,Supurna;Wu,Yi;Stack,MSharon
卵巢癌是妇科恶性肿瘤死亡的主要原因，也是北美妇女癌症相关死亡的第四大常见原因。据估计，每70名妇女中约有一人患卵巢癌，每100人中就有一人死于这种疾病。卵巢癌高死亡率的一个主要原因是缺乏适当的诊断工具，当肿瘤仍然局限于卵巢（FIGO I期）时，可以早期发现。大约75%的患者被诊断为既存播散性腹腔内转移（FIGO III或IV期）。虽然卵巢癌的5年生存率可高达90%，但远处转移妇女的生存率低于20%（霍斯金斯，1995）。因此，更详细地了解控制卵巢癌侵袭和转移的因素可能对患者的生存有重大影响。
Ovarian carcinoma is the leading cause of death from gynecologic malignancies and the fourth most common cause of cancer related deaths among North American women. Approximately one out of every 70 women is estimated to develop ovarian cancer and one in 100 will die from the disease. A major cause of the high mortality of ovarian cancer is the lack of proper diagnostic tools for early detection when the tumor is still confined to the ovaries (FIGO stage I). Approximately 75% of patients are diagnosed with pre-existing disseminated intra-abdominal metastases (FIGO stage III or IV). Although the 5-year survival rate for cancer localized to the ovary can be as high as 90%, women with distant metastases have a less than 20% survival rate (Hoskins, 1995). Thus, a more detailed understanding of the factors that control ovarian cancer invasion and metastasis may have a significant impact on patient survival.