Spatial sampling by dendritic trees in visual cortex.
Spatial sampling by dendritic trees in visual cortex.
复制标题
视觉皮层树突树的空间采样。
DOI：
10.1016/0006-8993(81)90435-2
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发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
Emerson,RC
中科院分区：
文献类型：
--
作者：
Coleman,PD;Flood,DG;Whitehead,MC;Emerson,RC
小猫被饲养在垂直或水平条纹的圆柱体中。暴露400-500h后，单个神经元的反应被确定为方波光栅刺激方向的函数。这些数据表明，饲养环境确实改变了一些小猫的取向偏好。根据高尔基-考克斯方法，对条纹饲养的小猫和对照小猫的视皮层进行灌输。用计算机显微镜对IV层星状细胞的树突进行三维追踪和分析。描述和讨论了分析枝晶空间分布的四种方法。文献9，31中先前描述的两种方法不够灵敏，无法检测暴露在垂直或水平条纹或对照环境中的小猫之间的任何差异。两种新开发的方法能够为视觉皮质树突树的饲养效应提供初步证据。这些新方法中更详细的描述了树突节段相对于标准脑轴的角度位置，作为到细胞体的距离的函数。通过这种树枝状角分布(DAD)图的方法获得的数据表明了一些结论。在条纹环境中饲养动物可能会影响视觉皮质第四层星状细胞的树突在神经纤维中的分布方式。选择性培养对树突分布的影响似乎不会延伸回树突树中最靠近细胞体的部分。在选择性环境中养育的这种影响可以通过假设在发育过程中树突的分布方式倾向于最大化突触后神经元的时空总和的效果来解释。
Kittens were reared in vertically or horizontally striped cylinders. After rearing exposures of 400–500 h, responses of single neurons were determined as a function of orientation of a square wave grating stimulus. These data suggest that the rearing environment did alter orientation preference in some of the kittens. The visual cortices of the stripe-reared kittens and of control kittens were impregnated according to a Golgi-Cox method. Dendrites of layer IV stellate cells were tracked and analyzed in three dimensions by a computer-microscope. Four methods of analyzing the spatial distribution of dendrites are described and discussed. Two methods previously described in the literature9,31were not sufficiently sensitive to detect any differences among kittens exposed to vertical or horizontal stripes or to a control environment. Two newly developed methods were able to provide initial evidence for rearing effects on dendritic trees in visual cortex. The more detailed of these new methods describes the angular location of dendritic segments, with respect to standard brain axes, as a function of distance from the cell body. Data obtained by means of this method of dendritic angular distribution (DAD) plots suggests a number of conclusions. Rearing animals in a striped environment may influence the way in which dendrites of layer IV stellate cells of visual cortex distribute themselves in the neuropil. The effect of selective rearing on dendritic distribution does not appear to extend back to those portions of the dendritic tree closest to the cell body. This influence of rearing in a selective environment may be explained by hypothesizing that during development dendrites distribute themselves in ways that tend to maximize the effects of spatio-temporal summation for the postsynaptic neurons.