PRESSOR RESPONSIVENESS TO VASOPRESSIN IN THE RAT WITH DOC-SALT HYPERTENSION
PRESSOR RESPONSIVENESS TO VASOPRESSIN IN THE RAT WITH DOC-SALT HYPERTENSION
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DOI：
10.1161/01.hyp.2.4.424
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发表时间：
1980-01-01
期刊：
影响因子：
8.3
通讯作者：
SHADE, RE
中科院分区：
文献类型：
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作者：
CROFTON, JT;SHARE, L;SHADE, RE
为了进一步表征加压素在DOC-盐高血压中的作用，研究了四组单侧肾切除大鼠：对照组大鼠不给予进一步治疗，DOC治疗组大鼠给予1%盐水饮用，或仅DIC或1%盐水治疗组大鼠对外源性加压素和血管紧张素II具有相似的升压反应。在DOC-盐组中，确定了两个大鼠群体：一个对加压素具有正常的升压反应，另一个对加压素具有显著增强的升压反应。反应性增强的发生率随治疗持续时间增加而增加。治疗1周后，1%生理盐水和DOC-盐组的尿加压素排泄量升高，DOC组的尿加压素排泄量升高4周后。然而，血浆加压素浓度升高，只有在与DOC和生理盐水治疗的大鼠。这表明，加压素是必不可少的扩张血容量的早期阶段的DOC-盐高血压，并作为一个直接的升压剂，只有在后期阶段。
To further characterize the role of vasopressin in DOC-salt hypertension, four groups of unilaterally nephrectomized rats were studied: control rats given no further treatment, rats treated with DOC and given 1% saline to drink, or rats treated with only DIC or 1% saline had similar pressor responses to exogenous vasopressin and angiotensin II. Within the DOC-salt group, two populations of rats were identified: one with normal pressor responsiveness to vasopressin, and one with markedly enhanced pressor responsiveness to vasopressin. Incidence of enhanced responsiveness increased with duration of treatment. Urinary excretion of vasopressin was elevated in the 1% saline and DOC-salt groups after 1 week of treatment, and in the DOC group after 4 weeks. However, the plasma vasopressin concentration was elevated only in the rats treated with both DOC and saline. It is suggested that vasopressin is essential for the expansion of blood volume in the early stages of DOC-salt hypertension, and functions as a direct pressor agent only in the later stages.