The Grueneberg ganglion of the mouse projects axons to glomeruli in the olfactory bulb
The Grueneberg ganglion of the mouse projects axons to glomeruli in the olfactory bulb
复制标题
DOI：
10.1111/j.1460-9568.2005.04468.x
复制
发表时间：
2005-11-01
影响因子：
3.4
通讯作者：
Mombaerts, P
中科院分区：
文献类型：
--
作者：
Fuss, SH;Omura, M;Mombaerts, P
Grueneberg神经节（GG）于1973年首次被描述，是鼻腔前端的一个箭头状神经元结构。它位于鼻中隔的两侧，在鼻前庭内，靠近鼻孔的开口。GG的功能和向大脑的投射模式尚不清楚。在这里，我们报道了小鼠GG神经元表达嗅觉标记蛋白，该蛋白通常在成熟的嗅觉或颏鼻感觉神经元中表达。约。每个GG中的500个细胞排列在几个密集的细胞簇中。单个细胞产生单个轴突，轴突相互缠绕形成一个神经束，向尾侧投射。轴突终止于嗅球的肾小球，一个或两个大的肾小球与多达10个较小的、弥漫性组织的半圆形肾小球相连，这些肾小球围绕着副嗅球的最前部。GG的发育大约在胚胎第16天开始，似乎在出生时完成；在出生后的发育过程中，细胞数量会轻微减少。GG的战略性位置、嗅觉标记蛋白的表达、嗅球特定位置的轴突向肾小球的投射以及早期发育表明，这种神经元结构在新生儿阶段具有特定的化学感觉功能。
First described in 1973, the Grueneberg ganglion (GG) is an arrow-shaped neuronal structure at the anterior end of the nasal cavity. It lines both sides of the nasal septum, within the nasal vestibule, close to the opening of the naris. The functions of the GG and the pattern of projections to the brain are not known. Here, we report that neurons of the mouse GG express olfactory marker protein, which is normally expressed in mature olfactory or vomeronasal sensory neurons. The approx. 500 cells in each GG are arranged in several densely packed cell clusters. Individual cells give rise to single axons, which fasciculate to form a nerve bundle that projects caudally. The axons terminate in glomeruli of the olfactory bulb, one or two large glomeruli associated with a semicircle of up to 10 smaller, somewhat diffusely organized glomeruli that surround the most anterior part of the accessory olfactory bulb. Development of the GG starts around embryonic day 16 and appears to be completed at birth; cell numbers then undergo a minor decrease during postnatal development. The strategic location of the GG, expression of olfactory marker protein, axonal projections to glomeruli at particular locations in the olfactory bulb and early development suggest that this neuronal structure performs specific chemosensory functions at neonatal stages.