THE EFFECT OF LITHIUM ON THE LOCOMOTOR STIMULATION INDUCED BY DEPENDENCE-PRODUCING DRUGS
THE EFFECT OF LITHIUM ON THE LOCOMOTOR STIMULATION INDUCED BY DEPENDENCE-PRODUCING DRUGS
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DOI：
10.1007/bf01249137
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
LILJEQUIST, S
中科院分区：
文献类型：
--
作者：
BERGGREN, U;ENGEL, J;LILJEQUIST, S
本文研究了Li对苯丙胺、乙醇、吗啡等依赖性药物诱发的运动刺激的影响。急性Li单独抑制小鼠的探索性多动而不影响基础运动活性，进一步支持Li具有神经节样行为特征的论点。急性锂预处理以剂量依赖方式抑制所有产生依赖性药物诱导的小鼠运动刺激。运动刺激后看到安非他明和乙醇似乎更抑制李比吗啡后看到的。两者结合的发现，李阿扑吗啡可乐定诱导的运动刺激消除突触前活动后没有影响，目前的数据表明，抑制作用的李介导的突触前儿茶酚胺能机制。
How Li affects locomotor stimulation induced by dependence-producing drugs such as amphetamine, ethanol and morphine was studied. Acute Li alone suppressed exploratory hyperactivity in mice without affecting basal locomotor activity, further supporting the contention that Li has a neurolept-like behavioral profile. Acute Li pretreatment suppressed locomotor stimulation in mice induced by all the dependence-producing drugs in a dose-dependent manner. Locomotor stimulation seen after amphetamine and ethanol appeared to be more suppressed by Li than that seen after morphine. Taken together with the finding that Li had no effect on apomorphine-clonidine-induced locomotor stimulation after elimination of presynaptic activity the present data suggest that the suppressive effect of Li is mediated via presynaptic catecholaminergic mechanisms.