Review of Neurosurgical fluorescence Imaging Systems for Clinical Application
Review of Neurosurgical fluorescence Imaging Systems for Clinical Application
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DOI：
10.3807/josk.2016.20.2.305
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发表时间：
2016-04-01
影响因子：
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通讯作者：
Kim, Kwang Gi
中科院分区：
文献类型：
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作者：
Kim, Hong Rae;Lee, Hyun Min;Kim, Kwang Gi
在神经外科的漫长历史中，已经开发了许多用于手术切除胶质瘤的荧光成像技术。还开发了用于神经胶质瘤的各种生物标志物、生化试剂和检测系统。本文就5-氨基乙酰丙酸（5-ALA）在胶质瘤检测中的应用作一综述。许多形式的荧光引导手术使用5-ALA，这对外科医生很有帮助。手术显微镜系统是通常与5-ALA一起使用的观察方法，而放大镜、内窥镜和外窥镜是更简单的替代方法。需要一种系统来最小化切除和神经外科手术期间出现的其他问题。这种增强的系统应该能够检测低级别肿瘤，并提供有关微创疾病的信息，从而提高生存率和更好的手术技巧。开发满足某些需求的系统将有助于保护患者的大脑功能，并扩大此类系统在神经外科中的使用。
A number of fluorescence imaging techniques for use in the surgical removal of glioma have been developed over the course of the long history of neurosurgery. Various biomarkers, biochemical agents, and detection systems for glioma have also been developed. This review focuses on 5-aminolevulinic acid (5-ALA), which is used to detect glioma. Numerous forms of fluorescence-guided surgery use 5-ALA, which is helpful to the surgeon. The surgical microscope system is the observational method generally used with 5-ALA, while the loupe, endoscope, and exoscope are simpler alternatives. A system is needed for minimal resection and other issues that arise during neurosurgery. Such an enhanced system should be able to detect low-grade tumors and provide information on microinvasive diseases, resulting in an improved survival rate and better surgical skills. Development of systems that fulfill certain needs would help protect the brain function of the patient and broaden the use of such systems in neurosurgery.