Time domain fluorescent diffuse optical tomography: analytical expressions
Time domain fluorescent diffuse optical tomography: analytical expressions
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DOI：
10.1364/opex.13.002263
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发表时间：
2005-04-04
期刊：
影响因子：
3.8
通讯作者：
Intes, X
中科院分区：
文献类型：
--
作者：
Lam, S;Lesage, F;Intes, X
已知光在组织中的传播在近红外光谱范围内是有利的。利用这一事实，新型分子造影剂被设计成在近红外线中发出荧光。这些新试剂的潜力是巨大的，因为它允许在体内非侵入性和定量地跟踪特定的分子事件。然而，为了监测这种化合物在厚组织中的生物分布，光传播的适当物理模型是必要的。为了恢复化合物分布的3D浓度，有必要执行基于模型的逆问题：漫射光学断层扫描。在这项工作中，我们专注于荧光漫射光学层析内表示的标准化玻恩方法。更确切地说，我们调查的荧光漫射光学层析成像的时间分辨测量的情况下的性能。解析推导了时间点扩散函数的不同矩，以构建正演模型。从零阶矩到二阶矩进行推导。基于相关配置的仿真验证了这种新的正演模型方法。与当前配方相比，使用这些新的分析解决方案实现了荧光漫射光学层析成像的增强性能。(C)2005年，美国光学学会。
Light propagation in tissue is known to be favored in the Near Infrared spectral range. Capitalizing on this fact, new classes of molecular contrast agents are engineered to fluoresce in the Near Infrared. The potential of these new agents is vast as it allows tracking non-invasively and quantitatively specific molecular events in-vivo. However, to monitor the bio-distribution of such compounds in thick tissue proper physical models of light propagation are necessary. To recover 3D concentrations of the compound distribution, it is necessary to perform a model based inverse problem: Diffuse Optical Tomography. In this work, we focus on Fluorescent Diffuse Optical Tomography expressed within the normalized Born approach. More precisely, we investigate the performance of Fluorescent Diffuse Optical Tomography in the case of time resolved measurements. The different moments of the time point spread function were analytically derived to construct the forward model. The derivation was performed from the zero order moment to the second order moment. This new forward model approach was validated with simulations based on relevant configurations. Enhanced performance of Fluorescent Diffuse Optical Tomography was achieved using these new analytical solutions when compared to the current formulations. (C) 2005 Optical Society of America.