Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymers
Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymers
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DOI：
10.1021/ja067184n
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发表时间：
2007-03-14
影响因子：
15
通讯作者：
Colvin, Vicki L.
中科院分区：
文献类型：
--
作者：
Yu, William W.;Chang, Emmanuel;Colvin, Vicki L.
在有机溶剂中形成的高质量纳米晶可以通过含有聚乙二醇或聚乙二醇组分的两亲共聚物完全溶解在水中。这些共聚物是使用马来酸酐偶联方案生成的，该方案允许各种类型的聚乙二醇聚合物(包括非官能化的和官能化的)偶联到疏水尾部。热重分析、尺寸排斥层析、低温透射电子显微镜和红外光谱都表明共聚物有效地包覆在纳米晶表面。这种复合纳米晶体-聚合物组件可以靶向识别具有Her2受体的癌细胞，如果其表面涂层含有聚乙二醇，则具有生物相容性。在半导体纳米晶体(例如量子点)的特殊情况下，水中的材料与最初在有机溶液中形成的材料具有相同的光谱和量子产率。
High-quality nanocrystals formed in organic solvents can be completely solubilized in water using amphiphilic copolymers containing poly( ethylene glycol) or PEG. These copolymers are generated using a maleic anhydride coupling scheme that permits the coupling of a wide variety of PEG polymers, both unfunctionalized and functionalized, to hydrophobic tails. Thermogravimetric analysis, size exclusion chromatography, cryogenic transmission electron microscopy, and infrared spectroscopy all indicate that the copolymers effectively coat the nanocrystals surfaces. The composite nanocrystal-polymer assemblies can be targeted to recognize cancer cells with Her2 receptor and are biocompatible if their surface coatings contain PEG. In the particular case of semiconductor nanocrystals (e. g., quantum dots), the materials in water have the same optical spectra as well as quantum yield as those formed initially in organic solutions.