Organ- and cell-specific immune responses are associated with the outcomes of intracerebral hemorrhage.
Organ- and cell-specific immune responses are associated with the outcomes of intracerebral hemorrhage.
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器官和细胞特异性免疫反应与脑出血的结果相关
DOI：
10.1096/fj.201700324r
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发表时间：
2018-01
期刊：
影响因子：
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通讯作者：
Shi FD
中科院分区：
文献类型：
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作者：
Zhang J;Shi K;Li Z;Li M;Han Y;Wang L;Zhang Z;Yu C;Zhang F;Song L;Dong JF;La Cava A;Sheth KN;Shi FD
严重的脑损伤会显著影响免疫反应;然而，这种影响发生的水平以及涉及的神经源性通路并没有很好的定义。在这里，我们使用MRI测量脑出血（ICH）患者的脾脏体积和组织扩散变化。我们观察到ICH后第3天毛细血管交换和脾脏收缩增加，第14天恢复。脾萎缩的程度与脑血肿大小相关，在存在严重脾萎缩的情况下观察到血肿周围水肿进展减缓。在细胞水平上，ICH患者入院时存在淋巴细胞减少症，并持续至14天。淋巴细胞减少症与观察到的脾脏变化不平行。此外，ICH合并感染患者存在显著的T细胞和NK细胞缺陷，功能结局较差。最后，在ICH小鼠模型中，脾脏萎缩可能与肾上腺素能输入和下丘脑-垂体-肾上腺（HPA）轴的神经支配有关。总之，ICH对免疫系统的深刻影响涉及交感神经支配和HPA轴的协调作用，其调节脾收缩和细胞免疫。张杰，Shi，K.，Li，Z.，Li，M.，汉，Y.，Wang，L.，美国，张志，Yu，C.，张福，松湖，加-地东，J. -F. LaCava，A.，Sheth，K.N.，Shi，F. -D.器官和细胞特异性免疫反应与脑出血的结局相关。FASEB J. 32，220 - 229（2018）。www.fasebj.org
Severe brain injury significantly influences immune responses; however, the levels at which this influence occurs and which neurogenic pathways are involved are not well defined. Here, we used MRI to measure spleen volume and tissue diffusion changes in patients with intracerebral hemorrhage (ICH). We observed increased capillary exchange and spleen shrinkage by d 3 post‐ICH, with recovery by d 14. The extent of spleen shrinkage was associated with brain hematoma size, and a reduced progression of perihematomal edema was observed in the presence of severe spleen shrinkage. At the cellular level, lymphopenia was present in patients with ICH at admission and persisted up to 14 d. Lymphopenia did not parallel the observed spleen alteration. In addition, patients with ICH with infection had significant deficiencies of T and NK cells and poor functional outcomes. Finally, in mouse models of ICH, spleen shrinkage could be related to innervations from adrenergic input and the hypothalamus‐pituitary‐adrenal (HPA) axis. In sum, the profound impact of ICH on the immune system involves the coordinated actions of sympathetic innervation and the HPA axis, which modulate spleen shrinkage and cellular immunity.—Zhang, J., Shi, K., Li, Z., Li, M., Han, Y., Wang, L., Zhang,Z.,Yu,C.,Zhang,F.,Song,L.,Dong,J.‐F.,LaCava,A.,Sheth,K.N.,Shi,F.‐D.Organ‐andcell‐specificimmune responses are associated with the outcomes of intracerebral hemorrhage. FASEB J. 32,220‐229 (2018). www.fasebj.org