Komodoquinone A, a novel neuritogenic anthracycline, from marine Streptomyces sp KS3
Komodoquinone A, a novel neuritogenic anthracycline, from marine Streptomyces sp KS3
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DOI：
10.1021/np030212k
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发表时间：
2003-10-01
影响因子：
5.1
通讯作者：
Kobayashi, M
中科院分区：
文献类型：
--
作者：
Itoh, T;Kinoshita, M;Kobayashi, M
从海洋沉积物中分离得到一株海洋链霉菌KS 3，经固态发酵分离得到一个新的蒽环类化合物科莫多醌A（1）及其苷元科莫多醌B（2）。1和2的绝对立体结构，除了糖部分，阐明的化学和物理化学证据的基础上。科莫多醌A（1）是一种独特的蒽环类抗生素，其中一个新的氨基糖连接到蒽环酮骨架的D-环上，并被发现在神经母细胞瘤细胞系Neuro 2A中诱导神经元细胞分化。
A novel anthracycline, komodoquinone A (1), and its aglycone, komodoquinone B (2), were isolated from the solid-state fermentation of the marine Streptomyces sp. KS3, which was isolated from marine sediment. The absolute stereostructures of 1 and 2, except for the sugar portion, were elucidated on the basis of chemical and physicochemical evidence. Komodoquinone A (1) is a unique anthracycline, in which a new amino sugar is connected to the D-ring of the anthracyclinone skeleton, and was found to induce neuronal cell differentiation in the neuroblastoma cell line, Neuro 2A.