The coactivator LXXLL nuclear receptor recognition motif
The coactivator LXXLL nuclear receptor recognition motif
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DOI：
10.1111/j.1399-3011.2004.00126.x
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发表时间：
2004-03-01
期刊：
影响因子：
--
通讯作者：
Burris, TP
中科院分区：
文献类型：
--
作者：
Savkur, RS;Burris, TP
核受体需要共激活子结合才能激活其同源靶基因的转录。配体通过与受体的配体结合域结合并诱导构象变化来调节核受体(NR)介导的辅活化子的募集，从而允许识别辅活化子蛋白中包含的特定基序。这个基序被称为NR box或LxxLL(其中L是亮氨酸，X是任何氨基酸)。在这里，我们回顾了结构域的发现以及它的特征。
Nuclear receptors require coactivator binding in order to activate transcription of their cognate target genes. Ligands regulate nuclear receptor (NR)-mediated recruitment of coactivators by binding to the ligand-binding domain of the receptor and inducing a conformational change allowing for recognition of a specific motif contained within the coactivator protein. This motif is known as the NR box or LXXLL (where L is leucine and X is any amino acid) domain. Here, we review the discovery of the domain as well as its characterization.