Practice Patterns Among United States Cardiologists for Managing Adults With Atrial Fibrillation (from the AFFECTS Registry)
Practice Patterns Among United States Cardiologists for Managing Adults With Atrial Fibrillation (from the AFFECTS Registry)
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DOI：
10.1016/j.amjcard.2009.11.046
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发表时间：
2010-04-15
影响因子：
2.8
通讯作者：
Waldo, Albert L.
中科院分区：
文献类型：
--
作者：
Reiffel, James A.;Kowey, Peter R.;Waldo, Albert L.
心房颤动的症状聚焦有效临床治疗策略（AFFECTS）登记研究旨在检查美国心脏病专家在美国心脏病学会、美国心脏协会和欧洲心脏病学会指南的背景下，在最近的里程碑式临床试验后进行的房颤（AF）治疗。AFFECTS中的大多数患者患有AF，无临床显著的结构性心脏病或仅无并发症的高血压。在所有入组人群（n = 1，461）中，64%的初始治疗策略为节律控制，36%为心率控制。在阵发性（n = 1，165）或持续性（n = 273）AF患者中，分别有67%和55%的患者接受了心律控制。将节律控制作为初始治疗目标的趋势随着年龄的增长而下降。在节律控制组中，大多数患者（74%）在登记期间也接受了心率控制剂，而25%的心率控制组接受了抗心律失常药物。大多数抗疟疾药物的首次处方是符合2001年（76%）和2006年（86%）指南的一线治疗。大多数第二处方也用于一线治疗。严重不良事件发生率较低。总之，本研究的数据提供了对AF患者社区治疗模式的深入了解，其中大多数患者没有临床显著的结构性心脏病或仅伴有单纯性高血压。(C)2010年爱思唯尔公司All rights reserved. (Am J Cardiol 2010;105：1122-1129）
The Atrial Fibrillation: Focus on Effective Clinical Treatment Strategies (AFFECTS) Registry was designed to examine atrial fibrillation (AF) treatment by United States cardiologists in the context of the American College of Cardiology, American Heart Association, and European Society of Cardiology guidelines after recent landmark clinical trials. Most patients in AFFECTS had AF without clinically significant structural heart disease or only uncomplicated hypertension. Among the all-enrolled population (n = 1,461), initial treatment strategies assigned were rhythm control in 64% and rate control in 36%. Among patients with either paroxysmal (n = 1,165) or persistent (n = 273) AF, 67% and 55%, respectively, were assigned rhythm control. The trend to assign rhythm control as the initial treatment goal decreased with age. In the rhythm-control group, most patients (74%) also received a rate-control agent during the registry, while 25% of those assigned to rate control received antiarrhythmic drugs. Most first prescriptions of antiarrhythmic drugs were for first-line therapy compliant with 2001 (76%) and 2006 (86%) guidelines. Most second prescriptions were for first-line therapies as well. Rates of serious adverse events were low. In conclusion, data from this study provide insight into community treatment patterns in patients with AF, most without clinically significant structural heart disease or with only uncomplicated hypertension. (C) 2010 Elsevier Inc. All rights reserved. (Am J Cardiol 2010;105:1122-1129)