Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)
Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)
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DOI：
10.1002/pros.20456
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发表时间：
2007-01-01
期刊：
影响因子：
2.8
通讯作者：
Carpten, John D.
中科院分区：
文献类型：
--
作者：
Baffoe-Bonnie, Agnes B.;Kittles, Rick A.;Carpten, John D.
背景非裔美国人遗传性前列腺癌（AAHPC）研究旨在招募早发性前列腺癌家族，满足≥ 4个受累标准。我们提出了一个类似的10厘米全基因组连锁（GWL）分析77个家庭，包括254个受影响的和274个未受影响的基因型。连锁分析揭示了所有77个家族在11q22、17p11和Xq21处的3个染色体区域，GENEHUNTER多点HLOD评分>= 1.3。一个家庭产生了全基因组的显着连锁证据（LOD = 3.5）的17p11区域与其他7个家庭>= 23在这个区域。29个无男性对男性（MM）传播的家庭在Xq21位点的峰值HLOD为1.62（α = 0.33）。在16个家系中，“> 6个受累”的两个新峰出现在2p21和22q12。这些染色体区域的基因组保证进一步的后续行动的基础上的假设，多个易感基因与适度的影响，或几个主要的基因分离的小子集的家庭。
BACKGROUND. The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >= 4 affected.METHODS. We present a similar to 10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped.RESULTS. Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores >= 1.3 for all 77 families at 11q22,17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families >= 23 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (alpha = 0.33) at the Xq21 locus. Two novel peaks >= 0.91 for the 16 families with '> 6 affected' occurred at 2p21 and 22q12.CONCLUSIONS. These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.