Dedifferentiated Chondrosarcoma
Dedifferentiated Chondrosarcoma
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DOI：
10.32388/qpw17u
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发表时间：
2020-02
期刊：
影响因子：
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通讯作者：
Andy Langdown
中科院分区：
文献类型：
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作者：
Andy Langdown
术语去分化软骨肉瘤已被应用于其中分化良好的软骨成分（有时持续时间明显较长）与分化程度较低的非软骨成分（被认为是相对较新的发展）相关的肿瘤3 '2。分化较低的成分通常具有纤维肉瘤或恶性纤维组织细胞瘤的组织学特征，尽管其他类型的恶性肿瘤，如骨肉瘤或横纹肌肉瘤已被排除。术语去分化软骨肉瘤意味着非软骨成分从软骨前体发展而来，尽管已经提出它可能来自坏死软骨区域周围的纤维组织6或来自未分化的干细胞7。与大多数其他软骨肉瘤相比，患有去分化软骨肉瘤的患者预后非常差;很少有患者在临床表现后存活一年。在本文中，我们报告了一例患有去分化软骨肉瘤的患者，其中非软骨成分最终被确认为恶性纤维组织细胞瘤，显示出与巨细胞瘤密切的组织学相似性。
The term dedifferentiated chondrosarcoma has been applied to tumors in which a well differentiated cartilaginous component, sometimes of demonstrably long duration, is associated with a less differentiated non-cartilaginous component that is assumed to be of relatively recent development3’2. The less differentiated component usually has the histological features of fibrosarcoma or malignant fibrous histiocytoma, although other types of malignant tumor, such as osteosarcoma or rhabdomyosarcoma, have been reported’#{176}”7. The term dedifferentiated chondrosarcoma implies that the non-cartilaginous component develops from a cartilaginous precursor, although it has been suggested that it may arise from fibrous tissue surrounding areas of necrotic cartilage’6 or from undifferentiated stem cells’7. Patients who have dedifferentiated chondrosarcoma, in contrast to most other chondrosarcomas, have a very poor prognosis; few patients survive one year after clinical presentation lO#{149} In this paper, we report a case of a patient who had dedifferentiated chondrosarcoma in which the non-cartilaginous component, ultimately recognized as malignant fibrous histiocytoma, showed a close histological resemblance to a giant-cell tumor.