A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation
A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation
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一种用于监测药物引起的肝毒性过程中过氧亚硝酸盐的肝细胞靶向近红外比率荧光探针及其修复
DOI：
10.1039/c9cc07017f
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发表时间：
2019-12-11
影响因子：
4.9
通讯作者：
Li, Chun-Yan
中科院分区：
文献类型：
--
作者：
Jiang, Wen-Li;Li, Yongfei;Li, Chun-Yan
设计了一种新型的肝细胞靶向近红外荧光探针Gal-NIR。Gal-NIR对ONOO-具有高灵敏度和高选择性。此外，该探针可以准确地靶向肝细胞，因此用于评估药物诱导的肝毒性及其通过在活细胞和小鼠中使用保肝药物的补救。
A novel hepatocyte-targeting near-infrared fluorescent probe named Gal-NIR is developed. Gal-NIR shows ratiometric response to ONOO- with high sensitivity and selectivity. Moreover, the probe can accurately target the hepatocyte, and thus is used for assessing drug-induced hepatotoxicity and its remediation by using hepatoprotective medicines in living cells and mice.