PHYSIOLOGIC RELATION BETWEEN CARDIAC CYCLE AND QT DURATION IN HEALTHY-VOLUNTEERS
PHYSIOLOGIC RELATION BETWEEN CARDIAC CYCLE AND QT DURATION IN HEALTHY-VOLUNTEERS
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DOI：
10.1016/0002-9149(89)90425-6
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发表时间：
1989-09-01
影响因子：
2.8
通讯作者：
JAILLON, P
中科院分区：
文献类型：
--
作者：
LECOCQ, B;LECOCQ, V;JAILLON, P
为探讨心电图QT间期与RR间期的关系，对23名健康青年志愿者(平均年龄24岁)进行了2项研究。研究一记录11例受试者(男5例，女6例)在静息状态、动态运动时、快速静脉注射异丙肾上腺素(0.2~12.8µg)、阿托品(2 Mg)前后的心电图(纸速50 mm/S，800次/受试者)。在研究2中，研究了12名受试者(男6名，女6名)在口服心得安(80 Mg)前后安静和运动时QT-RR的关系。结果证实休息和运动时QT间期和RR间期呈单指数个体关系：Qt=A-B·cntdot。EXP(-k.cntdot.RR)。通过合并研究1中11名受试者的RR-QT图，我们发现测量的QT间期=425-676。EXP(-3.7.cntdot.10-3)RR。在异丙肾上腺素诱发的心动过速期间，QT没有改变或增大，这可能表明心室复极的时间离散度增加。阿托品诱发的心动过速产生的变化与运动测试产生的变化相似。心得安不改变QT-RR关系，尽管RR间期延长。这些结果表明，生理QT-RR适应主要受副交感神经控制。
To determine the relation between QT duration and RR interval on the electrocardiogram, 2 studies were undertaken in 23 young healthy volunteers (mean age 24 years). In study 1, the electrocardiogram (paper speed at 50 mm/s, 800 measurements/subject) was recorded in 11 subjects (5 men, 6 women) at rest, during dynamic exercise and after rapid intravenous injections of isoproterenol (0.2 to 12.8 .mu.g), before and after intravenous atropine (2 mg). In study 2, the QT-RR relation was studied at rest and during exercise in 12 subjects (6 men, 6 women) before and after oral propranolol (80 mg). The results confirmed a monoexponential individual relation of the QT and RR intervals during rest and exercise: QT = A - B .cntdot. Exp(-k .cntdot. RR). By pooling the RR-QT plots from the 11 subjects in study 1, we found that the measured QT interval = 425-676 .cntdot. Exp (-3.7 .cntdot. 10-3) RR. During isoproterenol-induced tachycardia, QT either did not change or incrased and this may indicate an increase in temporal dispersion of ventricular repolarization. Atropine-induced tachycardia produced changes similar to those resulting from exercise testing. Propranolol did not change the QT-RR relation despite a lengthing in RR intervals. These results suggest that physiologic QT-RR adaptation is mainly under parasympathetic control.