Epoxidases Involved in the Biosynthesis of Type II Sex Pheromones
Epoxidases Involved in the Biosynthesis of Type II Sex Pheromones
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DOI：
10.1007/978-981-15-3082-1_8
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
T. Fujii;Y. Rong;Y. Ishikawa
中科院分区：
文献类型：
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作者：
T. Fujii;Y. Rong;Y. Ishikawa
在蛾类，利用烯基（II型）性信息素，选择性环氧化的双键中的烯烃信息素成分赋予其化学结构的进一步多样性。美国白蛾Hyphantria cunea和桑葚虎蛾Lemyra imparilis是两种以环氧烯（Z3，Z6，epo 9 -21：H）为主要信息素成分的粘虫。在这些物种中，我们最近确定了属于CYP 341家族的细胞色素P450（CYP）作为参与信息素前体Z3，Z6，Z9-21：H的Z9双键的特异性环氧化的酶。此外，属于不同家族的细胞色素P450（CYP 340）被鉴定为负责日本巨环首虫（LooperAscotisselenaria）中信息素前体Z3，Z6，Z9-19：H的Z3双键的特异性环氧化的酶，其使用epo 3，Z6，Z9-19：H作为主要信息素组分。这些发现表明，具有不同区域特异性的环氧酶（CYP）独立进化。
In moth species that utilize alkenyl (type II) sex pheromones, selective epoxidation of double bonds in the alkene pheromone components confers further diversity on their chemical structures. Two arctiids, the fall webwormHyphantria cuneaand the mulberry tiger mothLemyra imparilis, use the same epoxyalkene, Z3,Z6,epo9-21:H, as the main pheromone component. In these species, we recently identified cytochrome P450s (CYPs) belonging to the CYP341 family as enzymes involved in the specific epoxidation of a Z9 double bond of the pheromone precursor Z3,Z6,Z9-21:H. Furthermore, a cytochrome P450 belonging to a different family, CYP340, was identified as an enzyme responsible for the specific epoxidation of a Z3 double bond of the pheromone precursor Z3,Z6,Z9-19:H in the Japanese giant looperAscotis selenaria, which uses epo3,Z6,Z9-19:H as the main pheromone component. These findings suggest that epoxidases (CYPs) with different regio-specificities evolved independently.