FINE-STRUCTURAL STUDY OF INTERSTITIAL-CELLS ASSOCIATED WITH THE DEEP MUSCULAR PLEXUS OF THE RAT SMALL-INTESTINE, WITH SPECIAL REFERENCE TO THE INTESTINAL PACEMAKER CELLS
FINE-STRUCTURAL STUDY OF INTERSTITIAL-CELLS ASSOCIATED WITH THE DEEP MUSCULAR PLEXUS OF THE RAT SMALL-INTESTINE, WITH SPECIAL REFERENCE TO THE INTESTINAL PACEMAKER CELLS
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DOI：
10.1007/bf00319139
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发表时间：
1995-10-01
影响因子：
3.6
通讯作者：
SEKI, K
中科院分区：
文献类型：
--
作者：
KOMURO, T;SEKI, K
电镜观察表明，大鼠小肠深肌丛内有两种类型的间质细胞。第一种类型的细胞的特征在于成纤维细胞的超微结构，即发育良好的颗粒内质网、高尔基体和缺乏基底层。它们与环形肌细胞形成一些小的缝隙连接，并与含有许多突触小泡的轴突终末密切接触。它们可能在肌肉组织中传导电信号方面发挥作用。第二种类型的细胞的特征是许多大的缝隙连接，这些缝隙连接彼此互连并与环形肌细胞互连。它们的细胞质中含有丰富的细胞器，包括线粒体、颗粒内质网和高尔基体。它们与平滑肌细胞有些相似，有不完整的基膜、小窝和亚表面池。然而，它们不包含有组织的收缩装置，尽管在它们的过程中存在许多中间丝。它们还显示与含有突触小泡的轴突终末密切接触。这些富含缝隙连接的细胞可能是肠道的常规组成部分，并可能参与肠道运动的起搏活动。
Two types of interstitial cells have been demonstrated in close association in the deep muscular plexus of rat small intestine, by electron microscopy. Cells of the first type are characterized by a fibroblastic ultrastructure, i.e. a well-developed granular endoplasmic reticulum, Golgi apparatus and absence of the basal lamina. They form a few small gap junctions with the circular muscle cells and show close contact with axon terminals containing many synaptic vesicles. They may play a role in conducting electrical signals in the muscle tissue. Cells of the second type are characterized by many large gap junctions that interconnect with each other and with the circular muscle cells. Their cytoplasm is rich in cell organells, including mitochondria, granular endoplasmic reticulum and Golgi apparatus. They show some resemblance to the smooth muscle cells and have an incomplete basal lamina, caveolae and subsurface cisterns. However, they do not contain an organized contractile apparatus, although many intermediate filaments are present in their processes. They also show close contacts with axon terminals containing synaptic vesicles. These gap-junction-rich cells may be regular components of the intestinal tract and may be involved in the pacemaking activity of intestinal movement.