Aberrant patterns of local and long-range functional connectivity densities in schizophrenia.
Aberrant patterns of local and long-range functional connectivity densities in schizophrenia.
复制标题
精神分裂症中局部和远程功能连通密度的异常模式。
DOI：
10.18632/oncotarget.18441
复制
发表时间：
2017-07-18
期刊：
影响因子：
--
通讯作者：
Zhuo C
中科院分区：
文献类型：
--
作者：
Liu C;Zhang W;Chen G;Tian H;Li J;Qu H;Cheng L;Zhu J;Zhuo C
精神分裂症是一种大脑连接失调的疾病，精神分裂症患者的连接强度和连接数量均被破坏。功能连接密度（FCD）可以反映连接数量的变化。先前已证实精神分裂症患者的整体 FCD (gFCD) 发生变化；然而，大脑病理特征的另外两个指标局部FCD（lFCD）和远程FCD（lrFCD）的变化尚未被揭示。为了研究精神分裂症患者的 lFCD 和 lrFCD 改变，使用结构和静息态功能磁共振成像扫描对 95 名患者和 93 名匹配的健康对照进行了检查。 lFCD 和 lrFCD 使用 FCD 映射进行测量，并使用双样本 t 检验以体素方式识别差异，年龄和性别被认为会增加变异性。使用错误发现率方法进行多重比较，校正阈值P<0.05。我们的分析表明，lFCD 主要在中央后回、右侧距状沟和枕下回小叶减少，但在双侧皮质下区域增加。 lFCD 中的差异比 lrFCD 中的差异更加明显和复杂。总之，与之前关注连接强度的研究相比，我们的研究结果从连接数量的角度来看，表明精神分裂症是一种大脑连接障碍的疾病，特别影响局部功能连接网络，并支持精神分裂症与广泛的皮质功能连接/活动缺陷相关的假设，其中某些皮质中存在高和/或低连接/活动。 或皮层下区域。
Schizophrenia is a disorder of brain dysconnectivity, and both the connection strength and connection number are disrupted in patients with schizophrenia. The functional connectivity density (FCD) can reflect alterations in the connection number. Alterations in the global FCD (gFCD) in schizophrenia were previously demonstrated; however, alterations in two other indices of the pathological characteristics of the brain, local FCD (lFCD) and long-range FCD (lrFCD), have not been revealed. To investigate lFCD and lrFCD alterations in patients with schizophrenia, 95 patients and 93 matched healthy controls were examined using structural and resting-state functional magnetic resonance imaging scanning. lFCD and lrFCD were measured using FCD mapping, and differences were identified using a two-sample t-test in a voxel-wise manner, with age and gender considered to increase variability. Multiple comparisons were performed using a false discovery rate method with a corrected threshold of P<0.05. Our analysis showed that lFCD was primarily decreased in the postcentral gyrus, right calcarine sulcus, and inferior occipital gyrus lobule, but increased in the bilateral subcortical regions. The differences in lFCD were more pronounced and complicated than those in lrFCD. In summary, in contrast with previous studies that focused on the connection strength, our findings, from the perspective of connection number, indicate that schizophrenia is a disorder of brain dysconnectivity, particularly affecting the local functional connectivity network, and support the hypothesis that schizophrenia is associated with a widespread cortical functional connectivity/activity deficit, with hyper- and/or hypo-connectivity/activity coexisting in some cortical or subcortical regions.