Distant white-matter diffusion changes caused by tumor growth
Distant white-matter diffusion changes caused by tumor growth
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DOI：
10.1016/j.neurad.2012.05.006
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发表时间：
2013-05-01
影响因子：
3.5
通讯作者：
Sames, Martin
中科院分区：
文献类型：
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作者：
Zolal, Amir;Hejcl, Ales;Sames, Martin
目的：各种报告表明，肿瘤中的正常白色物质并不局限于常规成像中可检测到的信号异常。因此，本研究的目的是使用扩散张量成像（DTI）研究胶质母细胞瘤和转移瘤对白色物质的远处影响。材料和方法：分析了21名患有胶质母细胞瘤（n=12）或转移瘤（n=9）的患者的数据，这些患者的位置与基于DTI的锥体束重建的距离小于或等于10 mm，结果：在整个研究人群中，肿瘤同侧的各向异性分数（FA）显著低于肿瘤同侧（P
Objectives: Various reports have suggested that the involvement of normal-looking white matter with tumors is not limited to just signal abnormalities detectable on conventional imaging. Thus, the purpose of this study was to investigate the distant effects of glioblastomas and metastases on white matter using diffusion tensor imaging (DTI).Materials and methods: Data for 21 patients harboring a glioblastoma (n=12) or a metastasis (n=9) located at a distance of smaller or equal to 10 mm from a DTI-based reconstruction of the pyramidal tract were analyzed, using regions of interest (ROIs) placed along the pyramidal tracts in the cerebral peduncle distant (>15 mm) from the tumor.Results: For the whole study population, fractional anisotropy (FA) was significantly lower on the side ipsilateral to the tumor (P