A single pheromone receptor gene conserved across 400 million years of vertebrate evolution
A single pheromone receptor gene conserved across 400 million years of vertebrate evolution
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在 4 亿年脊椎动物进化过程中保守的单一信息素受体基因
DOI：
10.1093/molbev/msy186
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发表时间：
2018
影响因子：
10.7
通讯作者：
Nikaido Masato
中科院分区：
文献类型：
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作者：
Suzuki Hikoyu;Nishida Hidefumi;Kondo Hiro;Yoda Ryota;Iwata Tetsuo;Nakayama Kanako;Enomoto Takayuki;Wu Jiaqi;Moriya-Ito Keiko;Miyazaki Masao;Wakabayashi Yoshihiro;Kishida Takushi;Okabe Masataka;Suzuki Yutaka;Ito Takehiko;Hirota Junji;Nikaido Masato
信息素对于诱导不同动物物种的社会行为和性行为是至关重要的。犁鼻受体-1(V1R)基因编码信息素受体家族的成员，由于基因的广泛获得和丢失，在哺乳动物中在数量和谱系上都有很大的变化。在这里，我们报道了一个属于V1R家族的新的信息素受体基因，命名为AncientV1R(AncV1R)，它在大多数骨鱼(骨性脊椎动物)中都有，从鳍鱼的基本谱系到哺乳动物。用115个脊椎动物基因组对ancV1R进行的系统发育和共线分析表明，它代表了一个在脊椎动物进化过程中保守的同源基因。有趣的是，在一些四足动物中，V1R的缺失与高等灵长类、鲸类以及包括鸟类和鳄鱼在内的一些爬行动物的犁鼻器退化是一致的。此外，ancV1R在大多数成熟的犁鼻感觉神经元中都有表达，而CanonicalV1Rs的表达稀少，这与“一个神经元-一个受体”的规则相一致。我们的结果表明，从志留纪远古祖先那里继承的一个以前未被描述的V1R基因可能在脊椎动物犁鼻器官的进化中发挥了重要的功能作用。
Pheromones are crucial for eliciting social and sexual behaviors in diverse animal species. The vomeronasal receptor type-1 (V1R) genes, encoding members of a pheromone receptor family, are highly variable in number and repertoire among mammals due to extensive gene gain and loss. Here, we report a novel pheromone receptor gene belonging to theV1Rfamily, named ancientV1R(ancV1R), which is shared among most Osteichthyes (bony vertebrates) from the basal lineage of ray-finned fishes to mammals. Phylogenetic and syntenic analyses ofancV1Rusing 115 vertebrate genomes revealed that it represents an orthologous gene conserved for >400 My of vertebrate evolution. Interestingly, the loss ofancV1Rin some tetrapods is coincident with the degeneration of the vomeronasal organ in higher primates, cetaceans, and some reptiles including birds and crocodilians. In addition,ancV1Ris expressed in most mature vomeronasal sensory neurons in contrast with canonicalV1Rs, which are sparsely expressed in a manner that is consistent with the “one neuron–one receptor” rule. Our results imply that a previously undescribedV1Rgene inherited from an ancient Silurian ancestor may have played an important functional role in the evolution of vertebrate vomeronasal organ.