Associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white women diagnosed with breast cancer: the Breast Cancer Health Disparities Study.
Associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white women diagnosed with breast cancer: the Breast Cancer Health Disparities Study.
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诊断患有乳腺癌的西班牙裔和非西班牙裔白人女性中 ALDH1A1 多态性、饮酒量和死亡率之间的关联：乳腺癌健康差异研究。
DOI：
10.1007/s10549-017-4600-2
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发表时间：
2018
影响因子：
3.8
通讯作者：
Connor,AvonneE
中科院分区：
文献类型：
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作者：
Xia,Zhiyu;Baumgartner,KathyB;Baumgartner,RichardN;Boone,StephanieD;Hines,LisaM;John,EstherM;Wolff,Roger;Slattery,MarthaL;Connor,AvonneE
目的ALDH 1A 1是乙醛脱氢酶-1的主要同位素之一，参与正常造血干细胞的分化和保护，并在酒精敏感性和依赖性中发挥作用。我们评估了ALDH 1A 1多态性，饮酒量和死亡率之间的西班牙裔和非西班牙裔白色（NHW）乳腺癌（BC）的乳腺癌健康差异Study.MethodsNine单核苷酸多态性在ALDH 1A 1进行了评估920西班牙裔和1372 NHW妇女诊断为侵袭性BC事件。使用校正的考克斯比例风险回归模型估计风险比（HR）和95%置信区间（CI）。模型进行了分层的美洲原住民（NA）的血统和酒精consumption.ResultsA共443例死亡发生在一个中位随访时间为11年。调整多重比较的所有结果后，rs7027604与全因死亡率显著相关（HRAA= 1.40; 95%CI 1.13- 1.73，Padj = 0.018）。rs 1424482 CC基因型（HRCC= 1.69; 95%CI 1.20- 2.37，Padj = 0.027）和rs7027604 AA基因型（HRAA= 1.65; 95%CI 1.21- 2.26，Padj = 0.018）与非BC死亡率呈正相关。在长期轻度饮酒者中，rs 1888202与全因死亡率降低相关（HRCG/GG= 0.36; 95%CI 0.20-0.64），而在非饮酒者或中度/重度饮酒者中相关性不显著（Pinteration= 0.218）。与rs63319相关的全因死亡风险增加仅限于低NA血统的女性（HRAA= 1.53; 95%CI 1.19-1.97）。未来BC研究ALDH 1A 1和死亡率之间的关系应考虑饮酒和NA血统的修正作用。
PurposeALDH1A1, one of the main isotopes of aldehyde dehydrogenase-1 is involved in the differentiation and protection of normal hematopoietic stem cells and functions in alcohol sensitivity and dependence. We evaluated the associations betweenALDH1A1polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white (NHW) breast cancer (BC) cases from the Breast Cancer Health Disparities Study.MethodsNine SNPs inALDH1A1were evaluated in 920 Hispanic and 1372 NHW women diagnosed with incident invasive BC. Adjusted Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Models were stratified by Native American (NA) ancestry and alcohol consumption.ResultsA total of 443 deaths occurred over a median follow-up time of 11 years. After adjusting all results for multiple comparisons, rs7027604 was significantly associated with all-cause mortality (HRAA= 1.40; 95% CI 1.13–1.73,Padj= 0.018). The rs1424482 CC genotype (HRCC= 1.69; 95% CI 1.20–2.37,Padj= 0.027) and the rs7027604 AA genotype (HRAA= 1.65; 95% CI 1.21–2.26,Padj= 0.018) were positively associated with non-BC mortality. Among long-term light drinkers, rs1888202 was associated with decreased all-cause mortality (HRCG/GG= 0.36; 95% CI 0.20–0.64), while associations were not significant among non-drinkers or moderate/heavy drinkers (Pinteration= 0.218). The increased risk of all-cause mortality associated with rs63319 was limited to women with low NA ancestry (HRAA= 1.53; 95% CI 1.19–1.97).ConclusionsMultiple SNPs inALDH1A1were associated with increased risk of mortality after BC. Future BC studies examining the relationship betweenALDH1A1and mortality should consider the modifying effects of alcohol consumption and NA ancestry.