SOMATIC SENSORY RESPONSES IN THE ROSTRAL SECTOR OF THE POSTERIOR GROUP (POM) AND IN THE VENTRAL POSTERIOR MEDIAL NUCLEUS (VPM) OF THE RAT THALAMUS - DEPENDENCE ON THE BARREL FIELD CORTEX
SOMATIC SENSORY RESPONSES IN THE ROSTRAL SECTOR OF THE POSTERIOR GROUP (POM) AND IN THE VENTRAL POSTERIOR MEDIAL NUCLEUS (VPM) OF THE RAT THALAMUS - DEPENDENCE ON THE BARREL FIELD CORTEX
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DOI：
10.1002/cne.903190108
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发表时间：
1992-05-01
影响因子：
2.5
通讯作者：
EBNER, FF
中科院分区：
文献类型：
--
作者：
DIAMOND, ME;ARMSTRONGJAMES, M;EBNER, FF
从大鼠的胡须的S-I（桶）皮质的投影被分离成两个独立的路径-一个丘系通路中继腹后内侧核（VPM）的皮质桶，和一个丘系通路中继的后复合体（POM）的喙部之间的矩阵，上面，下面桶。在研究桶状皮层如何整合这些感觉通路之前，重要的是要了解更多关于对两个丘脑核团的各种输入的影响。基于更大的密度下降与上升的预测POm，它似乎可能是离皮质的输入起着重要的作用，在感觉活动的POm。为了测试这一点，POm和VPM细胞对感觉刺激的反应进行了测量之前，期间和之后的S-1皮层的抑制。S-I被抑制的应用镁或通过冷却，桶皮质的状态进行了评估，连续的脑电图。所有的VPM细胞（n = 8）积极响应胡须运动，即使桶皮质是深刻的抑郁症。相反，所有POm细胞（n = 9）未能响应晶须运动一旦桶皮质变得压抑，通常约25分钟后开始皮质冷却或镁的应用。POM细胞恢复反应后约30分钟皮质冷却或镁的洗脱停止。这些发现表明，感觉信息通过丘系通路的传输发生独立的状态的皮层，而通过丘系通路的传输取决于状态的皮层本身。
The projection from the whiskers of the rat to the S-I (barrel) cortex is segregated into two separate pathways-a lemniscal pathway relayed by the ventral posterior medial nucleus (VPM) to cortical barrels, and a paralemniscal pathway relayed by the rostral sector of the posterior complex (POm) to the matrix between, above, and below barrels. Before investigating how the barrel cortex integrates these sensory pathways, it is important to learn more about the influence of the various inputs to the two thalamic nuclei. Based on the greater density of descending versus ascending projections to POm, it seemed likely that corticofugal inputs play an important role in the sensory activity of POm. To test this, the responses of POm and VPM cells to sensory stimuli were measured before, during, and after suppression of the S-1 cortex. S-I was suppressed by application of magnesium or by cooling; the status of the barrel cortex was assessed continuously by an electrocorticogram. All VPM cells (n = 8) responded vigorously to whisker movement even when the barrel cortex was profoundly depressed. In contrast, all POm cells (n = 9) failed to respond to whisker movement once the barrel cortex became depressed, typically about 25 minutes after the start of cortical cooling or magnesium application. POm cells regained responsiveness about 30 minutes after the cessation of cortical cooling or the washoff of magnesium. These findings indicate that the transmission of sensory information through the lemniscal pathway occurs independently of the state of cortex, whereas transmission through the paralemniscal pathway depends upon the state of the cortex itself.