The inflammatory status of old age can be nurtured from the intestinal environment
The inflammatory status of old age can be nurtured from the intestinal environment
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DOI：
10.1097/mco.0b013e3282f2bfdf
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发表时间：
2008-01-01
影响因子：
3.1
通讯作者：
Schiffrina, Eduardo J.
中科院分区：
文献类型：
--
作者：
Guigoz, Yves;Dore, Joel;Schiffrina, Eduardo J.
综述目的最近的研究表明，老年人炎症状态与慢性疾病之间存在关联。该综述审查了解决低水平慢性炎症的出版物，并强调肠道水平上改变的宿主-微生物群相互作用如何有助于维持老年人的低全身炎症状态。最新研究结果对相关数量的健康老年人进行的第一项人群横断面研究显示，肠道微生物群与年龄相关的整体变化，非致病性革兰氏阴性菌（主要是肠杆菌）和 双歧杆菌的国家特定变化。无创方法使我们能够检测老年人群中的亚临床肠道炎症。此外，很少有研究报告免疫和/或炎症反应。然而，益生元、益生菌或合生元可能会改善老年人的炎症状况。总结更好地了解宿主-肠道微生物群串扰的机制将显着有助于设计针对粘膜水平免疫反应性的新型营养策略。
Purpose of reviewRecent studies suggest an association between inflammation status and the presence of chronic disease in the elderly. The review examines publications that address the low level of chronic inflammation and emphasizes how an altered host-microbiota interaction at the gut level could contribute to maintaining a low systemic inflammatory status in the elderly.Recent findingsThe first population cross-sectional studies with relevant numbers of healthy elderlies show age-related global changes in gut microbiota with a consistent increase in nonpathogenic Gram-negative mainly Enterobacteria and country-specific changes in bifidobacteria. Noninvasive methods have permitted us to detect subclinical intestinal inflammation in the elderly population. Furthermore, few studies report on immune and/or inflammatory response; however, prebiotics, probiotics or synbiotics might improve the inflammatory condition of the elderly.SummaryA better understanding of the mechanisms of host-gut microbiota cross-talk would significantly help in the design of novel nutritional strategies targeting immune reactivity at the mucosal level.