SYNTHESIS AND EVALUATION OF SOME ALKOXY-CONJUGATED, CHLORO-CONJUGATED, AND ACYLOXY-CONJUGATED STYRYL KETONES AGAINST P-388 LYMPHOCYTIC-LEUKEMIA AND AN EXAMINATION OF THE METABOLISM AND TOXICOLOGICAL EFFECTS OF 1-(META-ETHOXYMETHYLOXYPHENYL)-1-NONEN-3-ONE IN RATS
SYNTHESIS AND EVALUATION OF SOME ALKOXY-CONJUGATED, CHLORO-CONJUGATED, AND ACYLOXY-CONJUGATED STYRYL KETONES AGAINST P-388 LYMPHOCYTIC-LEUKEMIA AND AN EXAMINATION OF THE METABOLISM AND TOXICOLOGICAL EFFECTS OF 1-(META-ETHOXYMETHYLOXYPHENYL)-1-NONEN-3-ONE IN RATS
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DOI：
10.1002/jps.2600710912
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发表时间：
1982-01-01
影响因子：
3.8
通讯作者：
CROSS, BM
中科院分区：
文献类型：
--
作者：
DIMMOCK, JR;KIRKPATRICK, DL;CROSS, BM
合成了一些新的抗肿瘤药物1-(间乙氧甲氧基苯基)-1-壬烯-3-酮(IIIa)的类似物，并评价了其对小鼠P-388淋巴细胞白血病的抑制作用。在大鼠体内对IIIa的代谢研究表明，它被迅速隔离到大脑，因此可能被隔离到其他脂肪组织，这可能是尿液和粪便中没有IIIa和代谢物的原因。对大鼠的详细毒理学评估表明，由于出血进入腹部的红细胞吞噬功能，大鼠的肝脏和脾发生了显着的病理变化。
A number of analogs of a new antineoplastic agent, 1-(m-ethoxymethyloxyphenyl)-1-nonen-3-one (IIIa) were prepared and evaluated against murine P-388 lymphocytic leukemia. Metabolic studies of IIIa in rats showed that it was sequestered rapidly to the brain and, hence, probably to other adipose tissue, which may account for the absence of IIIa and metabolites in urine and feces. A detailed toxicological evaluation of IIIa in rats showed marked pathological changes principally in the liver and spleen as a result of erythrophagocytosis from bleeding into the abdomen.