Subcortical evoked activity and motor enhancement in Parkinson's disease.
Subcortical evoked activity and motor enhancement in Parkinson's disease.
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DOI：
10.1016/j.expneurol.2015.12.004
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发表时间：
2016-03
影响因子：
5.3
通讯作者：
Brown P
中科院分区：
文献类型：
--
作者：
Anzak A;Tan H;Pogosyan A;Khan S;Javed S;Gill SS;Ashkan K;Akram H;Foltynie T;Limousin P;Zrinzo L;Green AL;Aziz T;Brown P
运动表现的增强已被证明是在健康受试者和帕金森病患者的“矛盾运动”的形式对强烈刺激的反应。在这里，我们确定了一个中潜伏期诱发电位的局部场电位记录从丘脑底核，其规模的幅度与强度的刺激提供和相应的增强最大的手握的生物力学措施，独立的多巴胺能状态的帕金森氏病的受试者。相关的脚桥核（网状激活系统的关键组成部分）中类似诱发电位的记录为丘脑底核中的这种神经签名提供了支持，该神经签名是上行唤醒的一种新的相关物，从网状激活系统传播，对运动电路施加“激励”影响。未来操纵这个系统连接唤醒和运动性能可能提供一种新的方法，非多巴胺能增强运动功能减退性疾病，如帕金森氏病患者的运动性能。我们确定了帕金森病患者丘脑底核的诱发电位。这与通过大声的声音增强运动性能有关。在网状激活系统的脚桥核中也可以看到同样的情况。该电位可能是由阶段性唤醒引起的运动的神经标记。
Enhancements in motor performance have been demonstrated in response to intense stimuli both in healthy subjects and in the form of ‘paradoxical kinesis’ in patients with Parkinson's disease. Here we identify a mid-latency evoked potential in local field potential recordings from the region of the subthalamic nucleus, which scales in amplitude with both the intensity of the stimulus delivered and corresponding enhancements in biomechanical measures of maximal handgrips, independent of the dopaminergic state of our subjects with Parkinson's disease. Recordings of a similar evoked potential in the related pedunculopontine nucleus – a key component of the reticular activating system – provide support for this neural signature in the subthalmic nucleus being a novel correlate of ascending arousal, propagated from the reticular activating system to exert an ‘energizing’ influence on motor circuitry. Future manipulation of this system linking arousal and motor performance may provide a novel approach for the non-dopaminergic enhancement of motor performance in patients with hypokinetic disorders such as Parkinson's disease. We identify an evoked potential in the subthalamic nucleus of Parkinsonian patients. This scales with enhancements in motor performance by loud sounds. The same is seen in the pedunculopontine nucleus of the reticular activating system. The potential may be a neural marker of movement energization by phasic arousal.