Intracellular pH regulation in epithelial cells.
Intracellular pH regulation in epithelial cells.
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DOI：
10.1146/annurev.ph.48.030186.002113
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发表时间：
1986
影响因子：
18.2
通讯作者：
W. Boron
中科院分区：
文献类型：
--
作者：
W. Boron
预期上皮细胞中细胞内pH（pHi）的调节是极其重要的，因为几乎每个生物过程都是pH敏感的。此外，pH值的变化可能是重要的，在调节跨上皮溶质转运，在修改生化或内分泌功能，并在控制细胞生长和分化。某些上皮细胞被特殊化，用于将酸/碱等价物从上皮的一侧运输到另一侧。在这些细胞中，pHi调节可能与跨上皮酸/碱运输密切相关。这个简短的审查将被限制在离子转运过程中，研究在完整的上皮细胞，影响pHi调节。其他综述考虑了在整个上皮（26）或分离的膜囊泡（5）水平上进行的上皮酸/碱转运研究。
The regulation of intracellular pH (pHi) in epithelial cells is expected to be extremely important because virtually every biological process is pH sensitive. In addition, changes in pHi may be important in modulating transepithelial solute transport, in modifying biochemical or endocrinological function, and in controlling cell growth and differentiation. Certain epithelial cells are special ized for transporting acid/base equivalents through the cell, from one side of the epithelium to the other. In these cells pHi regulation may be intimately in terwoven with transepithelial acid/base traffic. This brief review will be con fined to ion-transport processes, studied in intact epithelial cells, that affect pHi regulation. Other reviews have considered epithelial acid/base transport studies at the level of whole epithelia (26) or isolated membrane vesicles (5).