The development of bone strength at the proximal radius during childhood and adolescence.
The development of bone strength at the proximal radius during childhood and adolescence.
复制标题
儿童期和青少年期近端桡骨骨强度的发展。
DOI：
10.1210/jcem.86.2.7186
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Friedrich Manz
中科院分区：
文献类型：
--
作者：
E. Schoenau;C. Neu;Frank Rauch;Friedrich Manz
目前对骨骼发育的研究主要集中在骨量上，但骨强度在功能上可能比质量更重要。因此，我们比较了皮质骨量（BMCcort）和皮质骨强度参数[极惯性矩、截面模量和强度应变指数（SSI）]的发育变化。使用外周定量计算机断层扫描在近端桡骨的 65% 部位进行分析。研究人群包括 469 名 6-40 岁的健康受试者（273 名女性）。在青春期前儿童（青春期 1 阶段）和青春期后（青春期 5 阶段和成人）中，男性的所有研究参数均显着较高。在青春期（青春期 2-4 阶段），性别差异通常较小。所有测量的参数随着年龄和青春期阶段显着增加。然而，尽管最小儿童和成人之间 BMCcort 的增加百分比在性别之间相似，但男性的极惯性矩、截面模量和 SSI 的增加较高。在 11 岁之后和青春期第 2 阶段之后的男性中，截面模量与 BMCcort 之间的比率始终较高。极惯性矩或 SSI 与 BMCcort 之间的比率也发现了类似的结果。这些结果表明，对于给定的骨量，在青春期第2阶段之后，男性的骨骼比女性更强。这反映了这样一个事实：在青春期，男性主要在骨膜表面添加骨骼，对骨骼强度的影响最大，而女性在皮质内表面添加骨骼，这对骨骼稳定性影响较小。女性青春期机械效率低下的皮质内并置的目的可能是为未来怀孕和哺乳创造钙储备。
Current investigations of bone development mostly focus on bone mass, but bone strength may be functionally more important than mass. Therefore, we compared the developmental changes in cortical bone mass (BMCcort) and parameters of cortical bone strength [polar moment of inertia, section modulus, and strength strain index (SSI)]. Analyses were performed at the 65% site of the proximal radius using peripheral quantitative computed tomography. The study population comprised 469 healthy subjects, 6-40 yr of age (273 females). Both in prepubertal children (pubertal stage 1) and after puberty (pubertal stage 5 and adults) all studied parameters were significantly higher in males. During puberty (pubertal stages 2-4) the gender-specific differences were generally somewhat smaller. All of the measured parameters increased significantly with age and pubertal stage. However, although the percent increase in BMCcort between the youngest children and adults was similar between the genders, the increases in polar moment of inertia, section modulus, and SSI were higher in males. The ratio between section modulus and BMCcort was consistently higher in males after the age of 11 yr and after pubertal stage 2. Similar results were found for ratios between polar moment of inertia or SSI and BMCcort. These results show that for a given bone mass, males have stronger bones than females after pubertal stage 2. This reflects the fact that in puberty males add bone mostly on the periosteal surface, where the effect on bone strength is highest, whereas females add bone on the endocortical surface, which has a small effect on bone stability. The purpose of the mechanically inefficient endocortical apposition in female puberty might be to create a reservoir of calcium for future pregnancy and lactation.
影响因子：
20.3
作者：
C. Kovacs;H. Kronenberg
通讯作者：
C. Kovacs;H. Kronenberg