Fundus autofluorescence in Stargardt macular dystrophy-fundus flavimaculatus
Fundus autofluorescence in Stargardt macular dystrophy-fundus flavimaculatus
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DOI：
10.1016/j.ajo.2004.02.056
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发表时间：
2004-07-01
影响因子：
4.2
通讯作者：
Fitzke, FW
中科院分区：
文献类型：
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作者：
Lois, N;Halfyard, AS;Fitzke, FW
目得：定量分析Stargardt黄斑营养不良-眼底黄斑（STGD-FFM）患者的自体荧光（AF）水平，并识别AF模式。设计：观察性比较研究。方法：前瞻性研究。地点：Moorfields眼科医院招募患者。研究人群：43名年龄20 - 40岁的STGD-FFM患者和35名年龄匹配的正常志愿者。右眼被任意选择AF的措施。干预：AF图像获得使用共焦扫描激光检眼镜。测量了整个黄斑的AF水平。并对房颤的分布进行了评价。36例患者（84%）获得了图形视网膜电图（PERG）和全视野ERG，并对AF水平的结果进行了评价。主要结果指标：AF、AF分布、PERG和ERG的值。结果：17例患者（39%）检测到黄斑中心正常或高AF，颞侧或鼻侧或两者均高AF。9例（21%）黄斑中心低AF，颞侧或鼻侧或两者均正常或低AF，6例（14%）整个黄斑AF水平正常。在11例（26%）中，发现了高、正常和低水平的AF。所有在黄斑中心检测到低水平AF的患者，以及颞侧或鼻侧或两者均正常或低水平AF的患者，均存在外周锥/杆功能障碍。没有测试的患者，有正常或高AF在中心凹和高AF的时间或鼻，或正常AF整个黄斑，有周边锥/杆dysfunction.CONCLUSION：AF是不是普遍高STGD-FFM。一些患者AF正常或较低。自体荧光模式似乎与功能异常有关。(C)2004年，Elsevier Inc. All rights reserved.
PURPOSE: To quantify autofluorescence (AF) levels in patients with Stargardt macular dystrophy-fundus flavimaculatus (STGD-FFM), and to identify patterns of AF.DESIGN: Observational, comparative study.METHODS: Prospective study.SETTINGS: Patients were recruited at Moorfields Eye Hospital.STUDY POPULATION: Forty-three STGD-FFM patients aged 20 to 40 years and 35 age-matched normal volunteers. The right eye was chosen arbitrarily for measures of AF.INTERVENTION: The AF images were obtained using a confocal scanning laser ophthalmoscope. Levels of AF across the macula were measured. The distribution of AF was also evaluated. In 36 patients (84%) pattern electroretinogram (PERG) and full-field ERG were obtained and results were evaluated with respect to levels of AF.MAIN OUTCOME MEASURES: Values of AF, AF distribution, PERG, and ERG.RESULTS: Normal or high AF at the center of the macula with high AF temporally or nasally or both was detected in 17 patients (39%). In nine (21%), low AF at the center of the macula with normal or low AF temporally or nasally or both was found. Levels of AF were normal throughout the macula in six patients (14%). In 11 (26%), high, normal, and low levels of AF were found. All patients tested with low AF at the center of the macula and normal or low AF temporally or nasally or both had peripheral cone/rod dysfunction. None of the patients tested that had normal or high AF at the fovea and high AF temporally or nasally, or normal AF throughout the macula, had peripheral cone/rod dysfunction.CONCLUSION: AF is not universally high in STGD-FFM. Some patients have normal or low AF. Autofluorescence patterns appear to relate to functional abnormalities. (C) 2004 by Elsevier Inc. All rights reserved.