Expression patterns of the p53 tumor suppressor gene and the mdm2 proto-oncogene in human meningiomas.
Expression patterns of the p53 tumor suppressor gene and the mdm2 proto-oncogene in human meningiomas.
复制标题
p53 抑癌基因和 mdm2 原癌基因在人脑膜瘤中的表达模式。
DOI：
10.1023/a:1005779406636
复制
发表时间：
1997
影响因子：
3.9
通讯作者：
George,DL
中科院分区：
文献类型：
--
作者：
Pykett,MJ;Landers,J;George,DL
Meningiomas represent a common class of tumors of the central nervous system. However, the molecular events underlying theirformation are poorly understood. Because altered expression ofthe p53 tumor suppressor gene and the mdm2 proto-oncogene havebeen demonstrated in a wide variety of tumors, we carried out studies to assess the possible involvement of these two genes in meningiomatumorigenesis. We used Western blot analysis to examine the levelof expression of the mdm2 and p53 proteins in a seriesof sixteen primary meningiomas and four meningioma cell lines. The data obtained from these studies suggest that elevated expression of the p53 or mdm2 protein products does not representa common event in the development of human meningiomas.
