A magnetic resonance imaging study of the entorhinal cortex in treatment-resistant depression
A magnetic resonance imaging study of the entorhinal cortex in treatment-resistant depression
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DOI：
10.1016/j.pscychresns.2007.11.005
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发表时间：
2008-07-15
影响因子：
2.3
通讯作者：
Fitzgerald, Paul B.
中科院分区：
文献类型：
--
作者：
Furtado, Christina P.;Maller, Jerome J.;Fitzgerald, Paul B.
尽管人们对这一领域的兴趣越来越大，但我们仍然缺乏对抑郁症和难治性抑郁症（TRD）的病理生理学的理解。内侧颞叶的作用，特别是海马，已被广泛牵连在抑郁症的病因。然而，相关的结构，如内嗅皮层还没有被系统地检查。本研究旨在检查TRD患者内嗅皮层（ERC）体积的可能异常。一组45名TRD患者和30名年龄和性别匹配的健康对照者进行了磁共振成像（MRI）。使用ANALYZE软件从MRI数据手动追踪ERC体积。分别在受试者组和性别之间进行方差分析，同时通过颅内体积（ICV）控制脑大小的影响。结果显示女性患者左侧ERC的体积显著减少。尽管是初步的，但我们的研究结果表明ERC的解剖异常可能会导致治疗抵抗。需要进行验证性的纵向研究，以确定这些异常是否早于抑郁症的发作，或者是一个更慢性的，耐药的疾病过程的结果。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Despite a growing interest in this area, we continue to lack an understanding of the pathophysiology of depression and of treatment-resistant depression (TRD) in particular. The role of the medial temporal lobe, particularly the hippocampus, has been widely implicated in the aetiology of depression. However, related structures such as the entorhinal cortex have not been systematically examined. This research study aimed to examine possible abnormalities in the volume of the entorhinal cortex (ERC) in TRD patients. A group of 45 TRD patients and 30 healthy age- and sex-matched controls underwent magnetic resonance imaging (MRI). ERC volumes were manually traced from MRI data using ANALYZE software. An analysis of variance was conducted between subject groups and in the sexes separately while controlling for the effects of brain size via intracranial volume (ICV). Results revealed significant reductions in the volume of the left ERC of female patients. Although preliminary, our findings suggest that anatomical abnormalities in the ERC may confer vulnerability to treatment resistance. Confirmatory longitudinal studies are required to determine whether these abnormalities predate the onset of depression or are the result of a more chronic, treatment-resistant course of illness. (c) 2007 Elsevier Ireland Ltd. All rights reserved.