PFAS exposure and overweight/obesity among children in a nationally representative sample
PFAS exposure and overweight/obesity among children in a nationally representative sample
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DOI：
10.1016/j.chemosphere.2020.128852
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发表时间：
2021-02-03
期刊：
影响因子：
8.8
通讯作者：
Qian, Zhengmin
中科院分区：
文献类型：
--
作者：
Geiger, Sarah Dee;Yao, Ping;Qian, Zhengmin
用途：全氟烷基物质（PFAS）是一类常用于消费品制造的人造化学品。全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）是研究最多的两种PFAS。这两者都存在于大多数美国人的血液中。PFAS与中度心血管疾病（CVD）结局相关，但其与肥胖（中度和晚期CVD的危险因素）的关系在很大程度上尚未得到证实。在此背景下，我们的目的是探讨PFAS与超重/肥胖和腹型肥胖儿童之间的关系。方法：我们在一个有代表性的样本中研究了PFOA和PFOS水平与体重指数（BMI）和腰围（WC）之间的关系（N = 2473）美国儿童，年龄在12-18岁之间，来自1999-2012年疾病控制和预防中心的国家健康和营养检查调查。超重/肥胖定义为年龄、性别特异性BMI z评分>=第85百分位数;腹部肥胖定义为年龄、性别特异性腰围>=第90百分位数。对于超重/肥胖BMI z评分，研究结果表明，对于PFOA暴露的第2个四分位数，OR = 1.42，95%CI：0.85-2.38; OR = 2.22（95% CI：1.20-4.13）; OR = 2.73（95% CI：1.10-6.74）。讨论：研究结果表明，PFOA升高和超重/肥胖的儿童之间的关联后，多变量调整。(C)2020爱思唯尔有限公司保留所有权利。
Purpose: Perfluoroalkyl substances (PFASs) are a class of manmade chemicals commonly used in consumer product manufacturing. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are two of the most highly studied PFASs. Both are present in the blood of the most Americans. PFASs are associated with intermediate cardiovascular disease (CVD) outcomes, but their relationship with obesity, a risk factor for intermediate and advanced CVD, remains largely unconfirmed. In this context, we aimed to explore the relationship between PFASs and both overweight/obesity and abdominal obesity among children.Methods: We examine associations between PFOA and PFOS levels, and Body Mass Index (BMI) and waist circumference (WC) in a representative sample (N = 2473) of US children, aged 12-18 years from the Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey 1999-2012. Overweight/obesity is defined as age-, sex-specific BMI z-score >= 85th percentile; abdominal obesity is defined as age-, sex-specific waist circumference >= 90th percentile.Results: Associations between PFASs and anthropometric outcomes show a dose-response relationship overall. For overweight/obese BMI z-score, findings indicate OR = 1.42 and 95% CI: 0.85-2.38 for quartile 2 of PFOA exposure; OR = 2.22 (95% CI: 1.20-4.13) for quartile 3 of PFOA exposure; and OR = 2.73 (95% CI:1.10-6.74) for quartile 4 of PFOA exposure.Discussion: Findings indicate an association between elevated PFOA and overweight/obesity among children after multivariable adjustment. (C) 2020 Elsevier Ltd. All rights reserved.