Retrieving randomized controlled trials from medline: a comparison of 38 published search filters
Retrieving randomized controlled trials from medline: a comparison of 38 published search filters
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DOI：
10.1111/j.1471-1842.2008.00827.x
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发表时间：
2009-09-01
影响因子：
3.8
通讯作者：
Haynes, Robert Brian
中科院分区：
文献类型：
--
作者：
McKibbon, Kathleen Ann;Wilczynski, Nancy Lou;Haynes, Robert Brian
背景：人们在Medline上搜索医疗保健干预试验以做出临床决策，或产生系统评价、实践指南或技术评估。寻找所有相关的、几乎没有外来材料的随机对照试验(RCT)是一项具有挑战性的工作。目的：提供用于从Medline检索随机对照试验的搜索过滤器的操作特性的比较数据。测试数据库包括在Medline中索引的161种临床期刊的手工搜索数据。计算敏感度、特异度和精密度。结果：术语数和操作特征有较大差异。将检索结果与单一词条“随机对照试验.pt”进行比较。(检索RCT的灵敏度为93.7%)，38个滤器中有24个的灵敏度在统计学上更高；6个的灵敏度至少为99.0%。其他四个过滤器的特异度(不检索非随机对照试验)在统计学上与单一术语(97.6%)没有区别或更好。精确度很差：只有两个过滤器的精确度(检索到的文章中RCT的比例)与单一术语的精确度(56.4%)在统计上相似--所有其他过滤器的精确度都较低。检索词越多，筛选器的特异度往往越低，尤其是在高灵敏度时。结论：存在许多随机对照试验筛选器(n=38)。这些比较数据可以指导RCT滤波器的选择。
Background:People search medline for trials of healthcare interventions for clinical decisions, or to produce systematic reviews, practice guidelines, or technology assessments. Finding all relevant randomized controlled trials (RCTs) with little extraneous material is challenging.Objective:To provide comparative data on the operating characteristics of search filters designed to retrieve RCTs from medline.Methods:We identified 38 filters. The testing database comprises handsearching data from 161 clinical journals indexed in medline. Sensitivity, specificity and precision were calculated.Results:The number of terms and operating characteristics varied considerably. Comparing the retrieval against the single term 'randomized controlled trials.pt.' (sensitivity for retrieving RCTs, 93.7%), 24 of 38 filters had statistically higher sensitivity; 6 had a sensitivity of at least 99.0%. Four other filters had specificities (non retrieval of non-RCTs) that were statistically not different or better than the single term (97.6%). Precision was poor: only two filters had precision (proportion of retrieved articles that were RCTs) statistically similar to that of the single term (56.4%)-all others were lower. Filters with more search terms often had lower specificity, especially at high sensitivities.Conclusion:Many RCT filters exist (n = 38). These comparative data can direct the choice of an RCT filter.