EVP-ABD-enhanced MRI to evaluate diffuse liver disease in a rat model.
EVP-ABD-enhanced MRI to evaluate diffuse liver disease in a rat model.
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EVP-ABD 增强 MRI 评估大鼠模型中的弥漫性肝病。
DOI：
10.1002/jmri.21385
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Renshaw,PerryF
中科院分区：
文献类型：
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作者：
Zuo,ChunS;Seoane,PeterR;Thomsen,Morgane;Gillis,Tim;Meloni,Edward;Harnish,PhillipP;Renshaw,PerryF
PurposeTo评估锰基MR成像对比剂EVP‐ABD在建立的大鼠肝炎模型中检测弥漫性肝病的可行性。在给予CCl 4后36小时，在3 T扫描仪上使用容积线圈MRI采集MR图像。通过尾静脉以10 μmol/kg的剂量给予EVP‐ABD。在EVP‐ABD给药前后采集多TI turboflash图像，以评价肝脏R1（=1/T1）值。18只大鼠接受不同剂量的CCl 4并完成增强前后MRI扫描和肝脏组织学评价。结果EVP‐ABD给药后肝脏R1和给药前后肝脏R1的变化ΔR1与CCl 4剂量显著相关。组织学评分和CCl 4剂量之间也存在显著相关性，尽管已知CCl 4剂量与组织学之间存在变异性。组织学评分与Δ R1之间存在显著相关性。结论EVP‐ABD‐增强MRI可检测CCl 4所致的弥漫性肝脏病变，EVP‐ABD后肝脏质子R1与CCl 4剂量及组织学评分之间存在显著相关性。J.磁共振成像2008;27：1317-1321.© 2008 Wiley利斯公司
PurposeTo evaluate the feasibility of using manganese‐based MR imaging contrast agent EVP‐ABD to detect diffuse liver disease in an established rat hepatitis model.Materials and MethodsHepatitis was induced by administration of CCl4in corn oil vehicle to rats intraperitoneally. MR images were acquired on a 3T scanner using a volume coil ≈36 hours after the administration of CCl4. EVP‐ABD was administered via a tail vein at a dose of 10 μmol/kg. Multi‐TI turboflash images were acquired to evaluate liver R1 (=1/T1) values before and after the EVP‐ABD administration. Eighteen rats received various doses of CCl4and completed pre‐ and postcontrast MRI scans and liver histologic evaluation.ResultsThe liver R1 after the EVP‐ABD administration and the change of the liver R1 before and after the administration, ΔR1, show significant correlations with the CCl4dose. A significant correlation was also found between the histologic scores and the CCl4doses despite known variability in the relationship of CCl4dose to histology. A significant correlation was found between the histologic score and ΔR1.ConclusionOur results indicate that EVP‐ABD‐enhanced MRI can detect diffuse liver disease generated by CCl4based on the significant correlation between proton R1 in liver following EVP‐ABD and the CCl4doses as well as the histologic scores. J. Magn. Reson. Imaging 2008;27:1317–1321. © 2008 Wiley‐Liss, Inc.