Involvement of an efflux system in high-level fluoroquinolone resistance of Shigella dysenteriae.
Involvement of an efflux system in high-level fluoroquinolone resistance of Shigella dysenteriae.
复制标题
外排系统参与志贺氏菌的高水平氟喹诺酮耐药性。
DOI：
10.1006/bbrc.1997.7902
复制
发表时间：
1998
影响因子：
3.1
通讯作者：
M. Kundu
中科院分区：
文献类型：
--
作者：
A. Ghosh;J. Ahamed;K. Chauhan;M. Kundu
志贺氏菌是越来越多的耐药细菌之一。喹诺酮类药物被广泛用于治疗志贺氏菌病。然而，喹诺酮类耐药已有报道，这就需要了解耐药的发生机制。我们证明，在没有gyrA突变的情况下，暴露在这些抗生素下的痢疾链球菌可能会产生高水平的氟喹诺酮耐药性，并涉及依赖质子动力(PMF)的外排系统。
Shigella dysenteriae represent one of the growing list of antibiotic-resistant bacteria. Quinolones are widely employed to treat shigellosis. However, quinolone resistance has already been reported, necessitating an understanding of the mechanisms of development of resistance. We demonstrate that high-level fluoroquinolone resistance of S. dysenteriae exposed to these antibiotics may occur in the absence of gyrA mutations and involve a proton motive force(pmf)-dependent efflux system.
影响因子：
56.9
作者：
NIKAIDO, H
通讯作者：
NIKAIDO, H